Center for Environmental Genomics and Integrative Biology

描述（由申请人提供）：环境基因组学和综合生物学中心（CEGIB）的主要目标是支持环境疾病病因学的杰出基础和转化研究，以及开发管理这些疾病的新方法。具有不同学科背景和研究兴趣的研究人员将共同努力：1)研究环境损伤的遗传、分子和细胞机制；2)评估基因组学研究的伦理、法律和社会影响；3)推进环境基因组学和整合生物学的新兴领域。CEGIB将提供科学领导和行政支持，以创建一个协同的跨学科和跨学科网络结构，将路易斯维尔大学的研究人员聚集在一起，专注于环境疾病的研究。该中心将支持生物信息学、生物统计学和计算生物学以及综合健康科学的设施核心。这些中心将提供专业知识和设施，以推进环境心脏病学、环境致癌以及健康和疾病的发展起源等领域的研究工作。该中心的结构还包括初级研究人员职业发展项目和试点项目计划，以鼓励开发新的研究方法和数据收集，从而实现其他资助机制。社区外展和教育核心已列入其中，以促进将科学信息转化为可用于缩小大路易斯维尔地区服务不足的西班牙裔人口的健康差距的知识。鉴于CEGIB在环境健康、分子生物学、生物信息学和计算生物学以及ELSI研究方面的专业知识和人才深度，以及对从床到床和从床到社区调查的强烈机构强调，CEGIB在实现其目标方面处于独特的地位。对环境基因组学和综合生物学的关注反映了其成员在推进环境相关疾病的分子研究和ELSI研究方面的兴趣。建立一个专注于环境基因组学和综合生物学的中心将进一步推动NIEHS的目标，即在最基本的层面上了解环境疾病的病因，并为在后基因组时代推进研究所的议程提供一个可见的基础设施。

DESCRIPTION (provided by applicant): The main goal of the Center for Environmental Genomics and Integrative Biology (CEGIB) is to support outstanding basic and translational investigations into the etiology of environmental disease and the development of new approaches to manage these conditions. Center investigators with diverse disciplinary backgrounds and research interests will combine their efforts to: 1) study genetic, molecular and cellular mechanisms of environmental injury, 2) evaluate the ethical, legal and social implications of genomics research, and 3) advance the emerging fields of environmental genomics and intergrative biology. CEGIB will provide scientific leadership and administrative support for creation of a synergistic inter- and trans-disciplinary network structure that brings together University of Louisville investigators to focus on the study of environmental disease. The Center will support facility cores in Bioinformatics, Biostatistics and Computational Biology, and Integrative Health Sciences. These cores will provide expertise and facilities to advance research efforts in the areas of environmental cardiology, environmental carcinogenesis, and developmental origins of health and disease. The Center structure also includes programs in Career Development for Junior Investigators and a Pilot Project Program to encourage development of novel research approaches and data collection that enable pursuit of other funding mechanisms. A Community Outreach and Education Core has been included to facilitate translation of scientific information into knowledge that can use be used to reduce health disparities of underserved Hispanic populations in the greater Louisville area. CEGIB is in a unique position to meet its objectives given the depth of expertise and talent in environmental health, molecular biology, bioinformatics and computational biology and ELSI research, and strong institutional emphasis on bench-to-bedside and bench-to-community investigations. The focus on environmental genomics and integrative biology reflects the interests of its members in advancing molecular investigations and ELSI research of environmentally related diseases. The creation of a Center with a resolute focus on environmental genomics and integrative biology will further NIEHS' goal to understand the etiology of environmental disease at its most fundamental levels and provide a visible infrastructure for advancement of the Institute's agenda in the post-genomic era.