Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC)

描述（由申请人提供）：堪萨斯州智力迟钝和发育障碍研究中心（MRDDRC）的竞争性更新要求五年的核心支持。堪萨斯MRDDRC，现在是它的第39个年头，在产生高效的行为干预方面发挥了重要的国际作用，其目的是为了预防和治疗智力迟钝和相关的继发性疾病，并在描述典型和非典型发育的潜在生物学基础知识。自成立以来，该中心一直支持行为和生物学研究的平衡组合。基于这一丰富的历史，该中心在未来的独特贡献将是发展生物学知情的行为和药理学干预和治疗方法。堪萨斯MRDDRC的使命是支持高质量的基础和应用研究，涉及智力迟钝的原因和预防，以及相关继发性疾病和相关发育障碍的预防和补救。为了完成这一任务，堪萨斯MRDDRC被设计为完成三个目标。首先，开发和支持与中心使命直接相关的新的跨学科基础和应用研究计划，将堪萨斯中心的科学家聚集在一起，并促进与其他机构的研究人员的合作。第二，提供具有成本效益的、科学生成的、最先进的核心服务、资源和设施，直接提高中心研究人员及其合作者所产生的科学质量和影响。第三，为规划、发展、管理、协调和传播与中心有关的研究活动提供高效、经济的系统。堪萨斯MRDDRC的研究计划是围绕四个综合的主题领域组织的，每个主题领域都反映了MRDD的一般主题，以及我们当前努力的科学方向和优势。这些主题是：1)语言、沟通和认知智力低下；2)智力低下的风险、预防与干预；3)智力迟钝的神经生物学；4)早期发育的细胞和分子生物学。为了协调和支助76名调查人员的研究活动和与这些主题有关的75个研究项目，提议设立四个核心单位：a)通讯和行政；b)生物行为测量；c)研究设计与分析；d)综合成像。

DESCRIPTION (provided by applicant): Core Support for five years is requested for the competitive renewal of the Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 39th year, has played a major international role in generating highly effective behavioral interventions aimed at the causes, prevention, and treatment of mental retardation and related secondary conditions, and in delineating basic knowledge of the underlying biology of typical and atypical development. Since its inception, the center has supported a balanced portfolio of behavioral and biological research. Building on this rich history, a unique contribution of the center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. The mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of associated secondary conditions and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission, bringing together scientists across the Kansas Center as well as promoting collaborative ventures with researchers at other institutions. Second, to provide cost-effective, scientifically generative, state of the art core services, resources, and facilities that directly enhance the quality and impact of science produced by center investigators and their collaborators. Third, to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The Kansas MRDDRC's research program is organized around four integrated thematic areas that each reflects a general topic central to MRDD as well as the scientific directions and strengths of our current efforts. These themes are: 1) language, communication, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 76 investigators and 75 research projects associated with these themes, four core units are proposed: a) Communication and Administration; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Integrative Imaging.