Kansas Mental Retardation Research Center

为堪萨斯大学智力迟钝和发育障碍研究中心（MRDDRC）的竞争性更新申请了五年的核心支持。堪萨斯MRDDRC，现在已经是它的第34个年头了，在产生针对智力迟钝的原因、预防和治疗的有效干预措施，以及在描述典型和非典型发育的潜在生物学基础知识方面发挥了重要作用。基于这一丰富的历史，该中心在未来的独特贡献将是发展生物学知情的行为和药理学干预和治疗方法。在这一生物行为学方向的背景下，堪萨斯MRDDRC的使命是支持高质量的基础和应用研究，这些研究与精神发育迟缓的原因和预防以及与精神发育迟缓和相关发育障碍相关的继发性疾病的预防和补救有关。为了完成这一任务，堪萨斯MRDDRC被设计为完成三个目标。第一，提供具有成本效益的、最先进的核心服务、资源和设施，直接提高与中心有关的项目所产生的科学质量。第二，为规划、发展、管理、协调和传播与中心有关的研究活动提供高效、具有成本效益的系统。第三，在中心研究人员之间，以及在中心研究人员与美国和世界其他研究中心的研究人员之间，发展和支持与中心使命直接相关的新的跨学科基础和应用研究计划。堪萨斯MRDDRC的研究项目围绕四个主题领域组织，反映了我们当前努力的科学方向和优势。这些主题是：1)语言、沟通障碍和认知智力低下；2)智力低下的风险、预防与干预；3)智力迟钝的神经生物学；4)早期发育的细胞和分子生物学。为了协调和支助66名调查人员和72个与这些主题有关的研究项目的研究活动，提议设立五个核心单位：a)行政事务和通讯；b)生物行为测量；c)研究设计与分析；d)生物行为成像与图形学；c)组织培养和单克隆抗体。

Core support for five years is requested for the competitive renewal of the Kansas University Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 34th year, has played a major role in generating effective interventions aimed at the causes, prevention, and treatment of mental retardation, and in delineating basic knowledge of the underlying biology of typical and atypical development. Building on this rich history, a unique contribution of the Center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. Within the context of this biobehavioral direction, the mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of secondary conditions associated with mental retardation and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to provide cost effective, state of the art core services, resources, and facilities that directly enhance the quality of science produced by projects associated with the Center. Second, to provide efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. Third, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission among center investigators, and between center investigators and investigators at other research centers throughout the United States and the World. The Kansas MRDDRC's research program is organized around four thematic areas that reflect the scientific directions and strengths of our current efforts. These themes are: 1) language, communication disorders, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 66 investigators and 72 research projects associated with these themes, five core units are proposed: a) Administrative Services and Communication; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Biobehavioral Imaging and Graphics; c) Tissue Culture and Monoclonal Antibodies.