ACTG 362:LONG-TERM ASSESSMENT FOR METABOLIC, CARDIOVASCULAR AND NEUROLOGIC COMP

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病临床试验组研究362是一项多中心、长期自然史研究，旨在评估既往CD 4计数<50个细胞/mm 3但在抗逆转录病毒治疗后增加至>100个细胞/mm 3的受试者的代谢、心血管和神经系统并发症。 ACTG 362的主要目标是： 心血管/代谢：研究长期抗逆转录病毒治疗（ART）受试者中高血压、胰岛素抵抗、空腹血糖异常和代谢综合征的发病率和患病率，以及随时间的变化。 寄生虫感染：检查机会性感染的发生率，描述其临床表现，并将其发生率和临床表现与免疫重建和病毒学控制的标志物相关联。 神经科：通过筛选神经心理学和神经学检查，检查认知障碍和周围神经病变的发病率和患病率，以及这些指标随时间的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS Clinical Trials Group Study 362 is a multicenter, long-term natural history study to assess metabolic, cardiovascular, and neurologic complications in subjects with a past CD4 count <50 cells/mm3 who increased to >100 cells/mm3 on antiretroviral therapy. The primary objectives for ACTG 362 are: Cardiovascular/Metabolic: to examine the incidence and prevalence, and changes over time of hypertension, insulin resistance, abnormal fasting glucose, and the metabolic syndrome in subjects on long-term antiretroviral therapy (ART). Opportunistic Infections: to examine the incidence of opportunistic infections, describe their clinical presentations, and correlate their incidence and clinical presentations with markers of immune reconstitution and virological control. Neurology: to examine the incidence and prevalence, and changes in these measures over time, of cognitive impairment and peripheral neuropathy as ascertained by a screening neuropsychologic and neurologic examination.