EFFECT OF LOW CARBOHYDRATE DIET ON SYMPTOMS OF IBS: A PROSPECTIVE PILOT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的目的是前瞻性地确定1)极低碳水化合物饮食对腹泻型肠易激综合征(IBS-D)患者的生活质量和胃肠道症状的影响；2)确定症状改善的可能的生理相关性，如与餐后5-羟色胺和5-羟IAA的释放、体重减轻和纤维含量有关。这些预期的发现可能有助于更好地理解饮食在IBS中的作用，并最终可能有助于改善患者护理。 北卡罗来纳大学将招收30名志愿者。将使用IBS严重程度指数来确定是否符合条件。所有参与者都将被给予两周的碳水化合物丰富饮食，然后是四周的非常低碳水化合物饮食。结果指标将包括使用日记卡的症状(标准化腹痛、大便形式和频率)、日常功能状态、患者生活质量以及餐后5-羟色胺和5-羟色胺的释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our purpose is to prospectively determine 1) the effect of a very low carbohydrate diet on quality of life and gastrointestinal symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS-D); and 2) to determine possible physiological correlates of symptom improvement, as related to post-prandial 5-HT and 5-HIAA release, weight loss and fiber content. These expected findings could lead to a better understanding of the role of diet in IBS and may ultimately help improve patient care. Thirty volunteers will be enrolled at UNC-CH. An index of IBS severity will be used to determine eligibility. All participants will be given two weeks of meals for a carbohydrate-rich diet, followed by four weeks of a very low carbohydrate diet. Outcome measures will include symptoms (standardized abdominal pain, stool form and frequency) using daily diary cards, daily function status, patient quality of life, and post-prandial release of 5-HT and 5-HIAA.