COBRE: OUHSC: PROTEOMICS/BIOINFORMATICS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 机构发展奖(IDEA)计划的目的是通过支持教师发展和加强位于NIH拨款总成功率历史最低的州的机构的研究基础设施，促进与健康相关的研究，并提高研究人员的竞争力。因此，我们成立了生物医学研究卓越中心(COBRE)，以视觉和眼科研究为主题。科布雷及其核心设施由NIH资助的老牌调查人员领导，其中包括五名年轻的调查人员，他们以前没有NIH R01支持的历史。松本博士在二维凝胶电泳法、质谱学和蛋白质组学数据分析方面拥有专业知识，是眼部蛋白质组学/生物信息学核心的负责人。2002年2月完成的人类基因组草图雄辩地预测了生物医学科学的未来。如果不能有效利用基因组数据，任何领域的生物医学科学都将进展缓慢。在此背景下，蛋白质组学/生物信息学核心为所有参与的视觉研究人员提供眼部蛋白质组学方面的相关技术和科学指导。Cobre蛋白质组学/生物信息学核心基于现有的P30国家眼科研究所视觉研究分析生化核心设施，具有运行二维凝胶电泳、图像存档和分析、凝胶内消化、用于鉴定目标蛋白质的多肽质量指纹图谱、通过分析多个二维凝胶数据进行数据挖掘以及通过互联网进行基因组数据库和相关生物信息搜索的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Institutional Development Award (IDEA) program is to foster health-related research and to increase the competitiveness of investigators through support of faculty development and enhancement of the research infrastructure of institutions located in states with historically low aggregate success rates for grant awards from the NIH. Thus, we established a Center of Biomedical Research Excellence (COBRE) with the thematic focus of Vision and Ophthalmologic Research. The COBRE and its Core Facilities are headed by established NIH-funded investigators and includes five young investigators who do not have a prior history of NIH R01 support. Dr. Matsumoto who has expertise in two-dimensional gel electrophresis, mass spectrometry, and the analyses of proteomics data directs the Ocular Proteomics/Bioinformatics Core. The completion of the draft of human genome in February 2002 eloquently predicts the future of biomedical sciences. Without an efficient use of genome data the biomedical sciences in any area will suffer from slow progress. Upon this background, the Proteomics/Bioinformatics Core assists all of the participating vision researchers with the pertinent techniques and scientific guidance in ocular proteomics. The COBRE Proteomics/Bioinformatics Core is based on the existing P30 National Eye Institute Vision Research Analytical Biochemistry Core Facility and renders the capability of running two-dimensional gel electrophoresis, image archiving and analysis, in-gel digestion, peptide mass fingerprinting for the identification of target proteins, datamining through the analysis of multiple two-dimensional gel data, and genome database and relevant bioinformation searches through the Internet.