OMEGA-3 FATTY ACIDS, ASPIRIN, AND PLATELET FUNCTION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 众所周知，鱼油中的欧米茄-3脂肪酸可以降低心脏病发作的风险，但其确切机制尚不清楚。 最早知道的鱼油的影响之一（最早见于爱斯基摩人）是延长出血时间。 出血时间主要受血小板在损伤部位聚集程度的影响。 像阿司匹林这样的药物抑制血小板功能，使血液不太可能凝结，（在某种程度上）这是一件好事-它降低了基于血液凝块的心脏病发作的风险。 (Of当然，过多的血小板抑制会导致出血，不是一件好事）。 我们知道阿司匹林是如何抑制血小板功能的，但omega-3脂肪酸是如何做到的呢？ 它们起作用的分子机制是什么？如果你同时服用鱼油和阿司匹林会发生什么？ 本项目将解决这些问题。 我们将招募10名健康受试者，然后在四种情况下进行血小板测试：基线，服用阿司匹林片剂后一天，服用鱼油4周后，服用鱼油时服用阿司匹林片剂后。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Omega-3 fatty acids from fish oils are known to reduce the risk for heart attacks, but the precise mechanisms by which they do this are not clear. One of the earliest know effects of fish oils (first seen in Eskimos) was prolonged bleeding times. Bleeding times are mostly influenced by how well the blood platelets aggregate at a site of injury. Drugs like aspirin inhibit platelet function, making the blood less likely to clot, and (to a point) this is a good thing -- it reduces the risk for blood-clot based heart attack. (Of course, too much platelet inhibition can lead to hemorrhage, not a good thing). We know how aspirin inhibits platelet function, but how do omega-3 fatty acids do it? What are the molecular mechanisms by which they operate, and what happens if you give fish oils and aspirin TOGETHER? This project will address these questions. We will recruit 10 healthy subjects and then do a panel of platelet tests in four settings: at baseline, one day after taking an aspirin tablet, after 4 weeks of taking fish oils, and after taking one aspirin tablet while on fish oil.