Howard University Research Scientist Award

描述(由申请人提供)： 这项竞争性更新研究科学家提案的目标是扩大在血红蛋白疾病和其他血液疾病方面的成功研究计划，这将建设霍华德大学的研究能力，并增加参与生物医学研究的少数族裔个人的数量。我们现在设想的研究的基本主题是减少健康差距，并加强霍华德大学在心肺和血液疾病研究方面的卓越表现。该计划的一个组成部分将是从NIH和其他来源获得额外的研究支持。科学目标：1.镰状细胞病和HIV感染中铁代谢紊乱-阐明铁代谢改变在镰状细胞病和HIV病发病机制中的作用。2.通过与镰状细胞病和先天性红细胞增多症在临床和分子水平上的比较，从低氧反应和镰状细胞病、先天性红细胞增多症和HIV-阐明缺氧反应在镰状细胞病并发症中的作用。检测低氧反应对HIV转录的影响。3.疟疾和艾滋病毒疾病中的免疫反应和贫血--确定免疫反应和铁代谢的变化是否与疟疾和艾滋病毒疾病中的贫血程度有关。教育具体目标：1.发展研究项目-为霍华德大学的教职员工和初级研究人员提供试点项目，并帮助他们发展独立的研究支持。2.实验室研究培训活动-为霍华德大学的本科生、硕士和博士生提供实验室经验。3.与国内和国际其他机构的研究合作--发展新的合作并扩大现有的合作。4.在霍华德大学组织研究研讨会--邀请这些合作机构的主要研究人员到霍华德大学参加研讨会。

DESCRIPTION (provided by applicant): The goal of this competitive renewal Research Scientist proposal is to expand a successful investigative program in hemoglobinopathies and other hematological diseases that will build the research capacity of Howard University and increase the number of minority individuals involved in biomedical research. The underlying themes of the research we now envision are to reduce health disparities and to enhance excellence in research into heart, lung and blood diseases at Howard University. An integral part of the program will be to obtain additional research support from the NIH and other sources. Scientific Specific Aims: 1. Disordered iron metabolism in sickle cell disease and HIV infection- elucidate the role of altered iron metabolism in the pathogenesis of sickle cell disease and HIV disease. 2. The hypoxic response and sickle cell disease, congenital polycythemia, and HIV- clarify the role of the hypoxic response in the complications of sickle cell disease by comparing patients with sickle cell disease and congenital polycythemia at the clinical and molecular levels. Examine the effect of the hypoxic response on HIV transcription. 3. Immune response and anemia in malaria and HIV disease- determine whether alterations in the immune response and in iron metabolism are related to the degree of anemia in malaria and HIV disease. Educational Specific Aims: 1. Developmental research projects- provide pilot projects for faculty and junior investigators of Howard University and help them develop independent research support. 2. Laboratory research training activities- provide laboratory experience to undergraduate, MS and PhD students at Howard University. 3. Research collaborations with other institutions nationally and internationally- develop new and expand existing collaborations. 4. Organize research seminars at Howard University- bring leading investigators from these collaborating institutions for seminars at Howard University.