Task Specific Project 1

结肠癌筛查需要准备大量的(通常至少是 L)用聚乙二醇片(歌利帝)清除结肠的大便和碎屑。患者通常会发现这个过程会 在接下来的结肠镜检查过程中，你会感到不适，也会感到疼痛、不适和痉挛。 那些高危人群，如溃疡性结肠炎、克罗恩病和家族综合症的病史 要求每年接受结肠镜检查。可以准确地评估结肠中是否存在 这一人群中的结肠发育不良可能会减少频率或延长两者之间的间隔 程序，从而节省时间、成本，并给患者带来不便。智能网新技术的发展 临床前和临床环境中的活体分子和细胞成像，特别是那些具有分子 肿瘤抗原的特异性，可能对检测结肠中的肿瘤具有重要意义， 恶性肿瘤复发的识别和治疗反应的监测。提高可获得性 临床SPECT/CT和PET/CT扫描仪可以促进新的肿瘤成像放射性配基向 诊所。该项目的成功结果将提供新的工具，应导致重要的临床前 进一步了解这种疾病的基因工程模型的生物学和治疗反应的机会 疾病。这些新型报告探针的成功验证将为新的临床诊断成像提供依据 通过评估高危人群的适当时机，可能导致改善患者护理的能力 结肠镜检查程序。

Screening for colon cancer requires preparation in the form of consumption of a large volume (usually at least 4 L) of polyethylene glycol (golytely) to clear the colon of stool and debris. Patients usually find this process to be unpleasant, and also experience pain, discomfort, and cramping on the ensuing colonoscopy procedure. Those who are at high risk, such as history of ulcerative colitis, Crohn's disease, and familial syndromes are required to undergo a colonoscopy annually. Methods that can accurately assess the colon for the presence of colonic dysplasia in this population may reduce the frequency or extend the interval in between these procedures, thus saving time, cost, and patient inconvenience. The development of novel techniques for in vivo molecular and cellular imaging in the pre-clinical and clinical setting, particularly those that have molecular specificity for neoplastic antigens, could have significant implications for the detection of neoplasia in the colon, identification of malignancy recurrence and monitoring of therapeutic response. The increased availability of clinical SPECT/CT and PET/CT scanners can facilitate the translation of new tumor imaging radioligands to the clinic. The successful outcome of this Project will provide new tools that should lead to important pre-clinical opportunities to further understand the biology and treatment response of genetically engineered models of this disease. Successful validation of these novel reporter probes will provide for new clinical diagnostic imaging capabilities that may lead to improved patient care by assessing those at high risk for the appropriate timing of colonoscopy procedures.