DEVELOPMENTAL CORE

8.发展核心 以下各节介绍了我们今后五年的主要发展活动。 8.a.教师招聘 确定教师招聘的优先顺序： 在我们的U54规划过程的早期，我们成立了一个特别工作组，开始制定我们将 包括在我们的跨学科健康差异研究重点中。跨学科问题特别工作组 2006年夏秋两季召开的健康差距研究包括： [Timothy Ahles，MSKCC精神病学]David Lounsbury，MSKCC行为科学 玛丽·阿尔波，CCNY生物学，萨拉·奥尔森，MSKCC流行病学 ？卡罗尔·布朗，MSKCC妇科肿瘤学？卢卡斯·帕拉，CCNY生物医学工程 杰克·伯克哈尔特，MSKCC行为科学，布鲁斯·拉普金，MSKCC行为科学 卡伦·哈伯德，CCNY生物学，MSKCC胃肠病学曼尼什·沙阿 CCNY Media的Edward Keller和CCNY心理学的Ann Marie Yali 传播艺术？MSKCC流行病学Anne Zauber 李月林，MSKCC精神病学和生物统计学 该工作队产生了下文所述主题。其中每一个主题都被确定为 一家或两家机构的调查人员优先考虑。在某些情况下，我们没有教员合作伙伴 确定在两个机构的特定领域工作的人员。然而，通过定期研讨会和 在持续的规划过程中，我们会就以下每一个范畴的持续发展提出建议： 社区干预与传播研究 癌症治疗对神经认知的影响 生物标志物和遗传风险的参与性研究和识别 增加癌症临床试验患者的多样性 应激的生物心理社会学研究 心理社会和行为干预的数学建模与仿真 U54实施和教师搜索 U54拨款给癌症生物学教授 8.B.拟议的试点项目 6个试点研究提案(项目2-7)包括在本叙述之后。这些项目是高度 响应伙伴关系的目标和未来方向。傅和Giancotti提出了一项基础研究 检查乳腺肿瘤的粘连和渗出，这一系列研究将有助于解释 转移机制(项目4)。其中两个项目具有很强的临床应用潜力： Pezzano和Sant‘Angelo对胸腺上皮祖细胞重建的潜能的研究 造血干细胞移植后的胸腺功能(项目6)和王和江筛选抗癌药物的工作 项目7)。另外两个试点项目强调了解决癌症健康问题的尚未开发的潜力 这种以社区为基础的初级保健做法存在差异。奥斯特罗夫和卢贝金研究了 患者导航器可以加强和扩大提供者鼓励患者戒烟的努力 (项目5)。Weiss和Binz-Sharf希望为初级保健医生提供知识和技能 帮助患者了解和考虑癌症诊断后的临床治疗试验(项目3)。 Hubbard、Ahles和Ragnauth的研究源于我们的跨学科研究特别工作组， 检查与化疗引起的认知功能下降有关的基因损伤(项目2)。其中两个 这些试点团队(Fu/Giancotti和Pezzano/Sant‘Angelo)有着长期的合作。两者都有 团队已经成功地从他们的US6飞行员那里获得了外部支持。这些飞行员是 不同于这些团队的早期工作，以及富有成效的研究路线的下一步合乎逻辑的步骤。 8.C.建议的完整项目 我们的完整项目(项目I)源于我们两名高级调查人员的富有成效的合作： 阿夫罗姆·卡普兰和尼尔·罗森。该团队提出了一项研究，以检查Hsp9O分子的使用 伴侣抑制物可促进癌细胞死亡。他们的项目支持该伙伴关系的目标 开展细胞生物学转化研究，支持癌症治疗进展。 8.D.建议的资源/基础设施开发 培训和教育 外展服务

8. Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: ¿ Timothy Ahles, MSKCC Psychiatry ¿ David Lounsbury, MSKCC Behavioral Sciences ¿ Mary Alpaugh, CCNY Biology ¿ Sara Olson, MSKCC Epidemiology ¿ Carol Brown, MSKCC Gynecological Oncology ¿ Lucas Parra, CCNY Biomedical Engineering ¿ Jack Burkhalter, MSKCC Behavioral Sciences ¿ Bruce Rapkin, MSKCC Behavioral Sciences ¿ Karen Hubbard, CCNY Biology ¿ Manish Shah, MSKCC Gastroenterology ¿ Edward Keller, CCNY Media and ¿ Ann Marie Yali, CCNY Psychology Communication Arts ¿ Anne Zauber, MSKCC Epidemiology ¿ Yuelin Li, MSKCC Psychiatry and Biostatistics This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Neurocognitive Impacts of Cancer Therapeutics Participatory Research and the Identification of Biomarkers and Genetic Risks Increasing the Diversity of Patients on Cancer Clinical Trials Biopsychosocial Research on Stress Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions U54 Implementation and Faculty Search U54 Funds Allocated for Cancer Biology Professor 8.b. Proposed Pilot Projects Six pilot research proposals (Projects 2-7) are included after this narrative. These projects are highly responsive to Partnership objectives as well as future directions. Fu and Giancotti propose a basic study to examine adhesion and extravasation of mammary tumors, a line of research that will help to explain mechanisms of metastasis (Project 4). Two of the projects have strong potential for clinical relevance: Pezzano and Sant'Angelo's study of the potential for thymic epithelial progenitors to reconstitute of thymic function after HSCT (Project 6) and Wang and Jiang's work on screening anti-cancer agents Project 7). Two additional pilot projects emphasize the untapped potential to address cancer health disparities in that community-based primary care practices. Ostroff and Lubetkin examine whether patient navigators can enhance and extend providers' efforts to encourage patients to quit smoking (Project 5). Weiss and Binz-Sharf want to provide primary care doctors with knowledge and skills to help their patients understand and consider therapeutic clinical trials after a cancer diagnosis (Project 3). Hubbard, Ahles and Ragnauth's study grew out of our Task Force on Transdisciplinary Research, to examine genetic damage associated with chemotherapy induced cognitive decline (Project 2). Two of these pilot teams (Fu/Giancotti and Pezzano/Sant'Angelo) have long standing collaborations. Both teams have been successful in obtaining outside support based on their Us6 pilots. These pilots are different from these teams' earlier work, and logical next steps in productive lines of research. 8.c. Proposed Full Project Our full project (Project i) grows out of the productive collaboration of our two senior investigators: Avrom Caplan and Neal Rosen. This team proposes a study to examine the use of Hsp9O molecular chaperone inhibitors to promote cancer cell death. Their project supports the Partnership's objective to carry out translational research in cell biology to support advances in cancer treatment. 8.d. Proposed Resource/Infrastructure Development Training and Education Outreach