CRF AND PERSONALITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 简介：童年创伤是许多精神疾病的危险因素，包括人格障碍。尽管人类童年创伤影响大脑导致人格障碍的机制尚不清楚，但存在与下丘脑-脑垂体轴有关的动物模型。在大鼠和猴子的动物模型中，有证据表明，早期生命创伤导致大脑促肾上腺皮质激素释放因子的表达上调，同时行为应激反应增加。已经收集的试点数据与儿童创伤史和成人脑脊液促肾上腺皮质激素释放因子水平之间的直接关系是一致的。该项目的具体目的是调查儿童时期的创伤史与成年人格障碍受试者的应激激素变化之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Childhood trauma is a risk factor for many psychopathologies, including personality disorder. Although the mechanism in humans by which childhood trauma affects the brain to cause personality disorder is unknown, animal models exist which implicate the hypothalamic-pitutary axis. Animal models in rats and monkeys find evidence that early life trauma causes an upregulation in the expression of brain corticotrophin-releasing factor along with increased behavioral stress reactivity. Pilot data that has already been collected is consistent with a direct realtionship between history of childhood trauma and adult CSF corticotropin-releasing factor levels. The specific aim of the proposed project is to investigate the realtionship between history of childhood trauma as measured by the Childhood Truama Questionnaire and stress hormone alterations in adult, personality disordered subjects.