FSH AND THE ONSET OF PUBERTY--GANIRELIX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定青春期时间的差异是否可以通过FSH调节多肽控制下的FSH精致程度的变化来解释。我们将通过比较性早熟和青春期延迟儿童FSH控制的调节，确定这些肽与青春期前和青春期儿童FSH产生的关系。在这项初步研究中，我们将使用促性腺激素释放激素激动剂刺激青春期轴，以确定激活素-A、抑制素-A和B以及卵泡抑素对青春期的反应。为了确定基础FSH分泌和FSH调节多肽张力，我们将使用特定的拮抗剂来阻断GnRH。这些研究应该有助于更好地理解FSH在控制青春期开始和青春期疾病发病机制中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this research is to determine whether differences in the timing of puberty may be explained by alterations in the elaboration of FSH under the control of the FSH-regulatory peptides. We will determine how these peptides relate to FSH production in prepubertal and pubertal children by comparing the regulation of FSH control in children with precocious puberty and delayed puberty. In this pilot study, we will stimulate the pubertal axis using an agonist of GnRH to determine the pubertal response of activin-A, inhibin-A and B and follistatin. To determine baseline FSH secretion and FSH-regulatory peptide tone, we will block GnRH with a specific antagonist. These studies should lead to a better understanding of the role of FSH in controlling the onset of puberty and the pathogenesis of pubertal disorders.