A POTENTIAL RECTAL MICROBICIDE VEHICLE AND SEMEN SURROGATE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将审查几个关键问题，以开发一种用于预防通过直肠性交传播人类免疫缺陷病毒(艾滋病毒)的杀微生物剂。建议进行三项研究。第一个将检查应用于直肠的候选杀微生物剂的分布和清除(CI)。第二项研究将检查应用于直肠的精液替代品的分布和清除情况。第三项研究将评估杀微生物剂载体和精液替代品的分布和清除情况。在每项研究中，比较了几种不同的方式(磁共振成像[MRI]、单光子发射计算机断层扫描[SPECT]、计算机断层扫描[CT]和通过内窥镜直接采样)，以确定最佳技术。研究将在与男性(MSM)发生性行为的健康志愿者男性(MSM)中进行，这些男性之前有接受性直肠交史，并报告使用过肛门扩张器。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine several questions critical to the development of a microbicide agent to be used for the prevention of transmission of the Human Immunodeficiency Virus (HIV) via rectal intercourse. Three studies are proposed. The first will examine the distribution and clearance (Cl) of a candidate microbicide vehicle applied to the rectum. The second will examine the distribution and clearance of a semen surrogate applied to the rectum. The third study will evaluate the distribution and clearance of the microbicide vehicle and semen surrogate together. In each study, several different modalities are compared (magnetic resonance imaging [MRI], single photon emission computed tomography [SPECT], computed tomography [CT], and direct sampling via endoscopy), in order to determine the optimal technique. Studies will be carried out in healthy volunteer men who have sex with men (MSM) who have a previous history of receptive rectal intercourse and who report use of anal dilators.