Modulation of leishmaniasis by the proinflammatory cytokines TNF
Modulation of leishmaniasis by the proinflammatory cytokines TNF
批准号:
nhmrc : 485807
负责人:
Prof Heinrich Korner
金额:
$19.26万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2012-12-31
中文摘要
我们已经建立了一个转基因小鼠模型,不能产生细胞因子肿瘤坏死因子。这种细胞因子在炎症反应开始时分泌。如果这些老鼠感染了寄生虫,它们就无法治愈感染,很快就会死亡。我们可以证明这些小鼠不能调节开始的炎症反应,也不会在感染部位形成细胞浸润。
英文摘要
We have established a mouse model that has been genetically modified and cannot produce the cytokine tumour necrosis factor. This cytokine is secreted in the beginning of the inflammatory response. If these mice are infected with a parasite they are not able to heal the infection and die quickly. We can demonstrate that these mice cannot regulate the beginning inflammatory response and do not form a cellular infiltrate at the site of infection.
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会议论文
Absence of CC chemokine receptor 6 dysregulates the humoral immune response.
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批准号:nhmrc : 1004592
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项目类别:Project Grants
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资助金额:$35.0万
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财政年份:2011
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负责人:Prof Heinrich Korner
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依托单位:
Upgrade of comparative phenotypical and functional cell analysis at James Cook University
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批准号:LE0668450
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$10.0万
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财政年份:2006
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负责人:Prof Heinrich Korner
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依托单位:
Biological function of the chemokine receptor 6 expression on B cells
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批准号:nhmrc : 329210
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项目类别:NHMRC Project Grants
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资助金额:$16.1万
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财政年份:2005
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负责人:Prof Heinrich Korner
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依托单位:
海外基金