Institutional Training Grant in the Genomic Sciences

描述(由申请人提供)：基因组科学培训计划(GSTP)正在帮助培养具有跨多个学科优势的新一代基因组科学家。这里提出的研究培训机会的主要动机是基于一组迅速增长的重大生物学和遗传学问题，这些问题现在可以得到解决，因为产生和解释日益复杂的数据集的新技术阐明了丰富的基因组数据。生物研究的新基因组方法要求科学家在几个领域都有知识和技能，并以有效的方式加强新的见解或发明。因此，开发用于创建和解释大规模实验工作的新工具是GSTP所关注的，它将来自多个领域(生物学、遗传学、物理科学、工程学、计算机科学和统计学)的研究方法进行教学交织，这些方法分别用于补充受训者的核心学科重点，但建立在基因组科学的成就和知识基础上。鉴于威斯康星大学令人难以置信的丰富的科学和工程领域，GSTP能够招募到非常先进的质谱学、微阵列技术、生物设备并利用这些优势在蛋白质组学、转录、代谢组学和基因组生物学方面进行尖端研究的优秀实习生。这些突破性的发展推动了许多学员和培训人员成为跨部门、中心和其他培训项目的重要合作的“磁铁”。我们建议，对于这一计划的更新，我们将继续这一重点，并增加对GSTP的程序性评估和对URM学员的更多接纳。我们要求每年为培训提供资金：10名博士后(1-3年)、4名博士后(1-3年)和2名短期(0.25年期)实习生；我们将寻找具有最近本科生和研究生学位的实习生。现代医疗实践越来越依赖于基因组研究的成果来进行新的诊断、药物和其他治疗。我们建议培训那些将开发系统的科学家，这些系统将使生物医学研究人员和普通公众能够更多地使用基因组信息。

DESCRIPTION (provided by applicant): The Genomic Sciences Training Program (GSTP) is helping to produce the new generation of genomic scientists with strengths spanning multiple disciplines. The primary motivation for the research training opportunities proposed here is predicated on the rapidly growing set of significant biological and genetics-based questions that can now be addressed given the wealth of genomic data elucidated by new technologies that generate and interpret increasingly complex data sets. The new genomic approaches to biological investigation demand scientists who are knowledgeable and skilled across several fields in effective ways that potentiate new insights or inventions. Accordingly, the development of new tools for the creation and interpretation of large-scale experimental efforts is what GSTP has focused on by the didactical interweaving of investigative approaches drawn from multiple fields (biology, genetics, physical sciences, engineering, computer science, and statistics) that were individually contoured for complementing a trainee's core disciplinary focus, yet built upon achievement and knowledge within the genomic sciences. Given the incredibly rich scientific and engineering span of the University of Wisconsin, GSTP was able to recruit outstanding trainees who greatly advanced mass spectroscopy, microarray technology, bio-devices, and created new applications exploiting these advantages for cutting-edge investigation into proteomics, transcription, metabolomics, and genome biology. These groundbreaking developments have propelled many trainees and trainers to become "magnets" for significant collaborations reaching across departments, centers, and other training programs. We propose that for the renewal of this program that we continue this focus with added emphasis on programmatic evaluation of GSTP and increased embracement of URM trainees. We request funding for training on a yearly basis: 10 predoctoral (1-3 yrs), 4 postdoctoral (1-3 yrs), and 2 short-term (0.25 yr) trainees; we will seek trainees with recent undergraduate and graduate degrees. Modern medical practice is increasingly relying on the fruits of genomic research for new diagnostics, drugs, and other therapies. We propose to train scientists who will be developing the systems that will enable greater use of genomic information for biomedical researchers and the general public.