UCHSC Diabetes and Endocrinology Research Center

描述(由申请人提供)： 2000年，科罗拉多大学健康科学中心(UCHSC)芭芭拉·戴维斯儿童糖尿病中心(BDC)成立了糖尿病和内分泌研究中心(DERC)，汇集了一批来自不同教职和研究背景的独特的基础和临床科学家，以提高该大学糖尿病和内分泌研究的生产率和质量。自成立以来的五年中，DERC研究基地的基础研究拨款收入增加了两倍，达到640万美元，临床研究收入增加了六倍，达到490万美元，主要来自NIH来源。在研究基地的大多数领域，包括胰岛发育生物学、人类胰岛移植、自身免疫和糖尿病转化研究，已经制定了新的计划项目和联盟资金。2005年，UCHSC的大部分部门将搬到菲茨西蒙斯新校区，BDC将建造一个11万平方米的新中心。FT，比现在的大楼大三倍多。因此，这种相互竞争的更新是在一个令人兴奋和具有挑战性的时刻到来的，因为NIH糖尿病路线图的实施机会巨大。新的DERC将有58个成员，高于前一个时期的33个。许多成员是通过外部审查的DERC试点和可行性计划招募的，我们计划将该计划从每年三个奖项扩大到五个奖项，每个奖项为50,000美元。细胞学、生物资源、分子资源以及临床和信息学方面的1个行政核心和4个生物医学核心将围绕现有专业知识和大型仪器构建，以具有成本效益的方式向最多的调查人员提供最先进的技术。每个核心将在新建筑中有定制的专用空间，并将与UCHSC的其他核心设施互联，特别是在小鼠基因靶向、微阵列分析、蛋白质组学和生物信息学领域。扩大的研究基础还解决了利用南加州大学及其附属机构(如国家犹太医学研究中心)的合作者纳入这些领域专门知识的需要。需要一些新设备才能使DERC堆芯充分运行，当价格超过10,000美元时，已申请作为配套资金。培训是DERC的一个重要组成部分，培训范围从分子生物学和组织学程序方面的“床与早餐”项目，到参与新的NIH培训补助金和K08奖项。DERC成员参加一系列研讨会、期刊俱乐部和年度研讨会。Hutton博士和Eisenbarth博士将与DERC和UCHSC调查人员的执行和指导委员会一起对DERC进行行政监督。由糖尿病领域的杰出研究人员组成的外部咨询委员会成员被任命进行定期实地考察，以审查DERC的科学目标和实现这些目标的进展情况。DERC的活动将通过一个网站(http://www.iicnsc.edu/inisc/diabetes/derc))广泛传播，该网站也是向DERC成员提供的以折扣费为基础的核心服务的广告、订购和账单的主要渠道。

DESCRIPTION (provided by applicant): The establishment of a Diabetes and Endocrinology Research Center (DERC) at the Barbara Davis Center for Childhood Diabetes (BDC) at the University of Colorado Health Sciences Center (UCHSC) in 2000 brought together a unique group of basic and clinical scientists from different faculty and research backgrounds to enhance productivity and the quality of diabetes and endocrinology research in the university. In the five years since its foundation, basic research grant income of the DERC research base has increased two-fold to $6.4 million and clinical research income six-fold to $4.9 million mainly from NIH sources. New Program Project and Consortium funding has been developed in most areas of the Research Base including islet developmental biology, human islet transplantation, autoimmunity and diabetes translational research. In 2005 most UCHSC departments will move to the new Fitzsimons campus and the BDC will build a new Center of 110,000 sq. ft., more than three times large than the current building. This competing renewal thus comes at an exciting and challenging time of immense opportunity for implementation of the NIH roadmap for diabetes. The new DERC will have 58 members, up from 33 in the previous period. Many of the members were recruited through the externally-reviewed DERC Pilot and Feasibility Program which we plan to expand from three to five awards per year at $50,000 each. An Administrative and four Biomedical Cores in Cytometry, Bioresources, Molecular Resources and Clinical and Informatics will be structured around existing expertise and large instrumentation to deliver state-of-the-art technologies to the greatest number of investigators in a cost-effective manner. Each of the Cores will have customized dedicated space in the new building and will interconnect with other UCHSC Core facilities notably in the areas of mouse gene targeting, microarray analyses, proteomics and bioinformatics. The expanded Research Base also addresses the need to include expertise in these areas using collaborators from within UCHSC and its affiliates such as the National Jewish Medical Research Center. Some new equipment is needed to make the DERC Cores fully operational and has been requested as matching funds on the application when exceeding $10,000 in price. Training is an important component of the DERC and ranges from "Bed and Breakfast" programs in molecular biology and histological procedures to participating in new NIH training grants and K08 awards. DERC members participate in a series of seminars, journal clubs and an annual workshop. Dr. Hutton, Ph.D., and Dr. Eisenbarth, M.D., Ph.D., will provide administrative oversight of the DERC along with Executive and Steering committees of DERC and UCHSC investigators. The External Advisory Board Members, comprised of distinguished investigators in the field of diabetes are appointed to perform periodic site visits to review the DERC scientific goals and progress towards them. The activities of the DERC will be broadly disseminated through a website (http://www.iicnsc.edu/inisc/diabetes/derc) that also serves as the major conduit for the advertising, ordering and billing for Core services that are offered on a discounted fee-for-service basis to DERC members.