EXERCISE DELAYS DIABETIC HEART DISEASE BY REDUCING ADIPOSE-RELATED INFLAMMATION

描述(申请人提供)：随着肥胖症在美国的爆炸性增长，2型糖尿病在许多人群中的发病率上升，特别是在非洲和西班牙裔美国人群体中。2型糖尿病表现为心血管、眼部、胃肠、感觉和皮肤系统的破坏性并发症。三分之二的糖尿病死亡是由心脏病和中风引起的。患心脏病的风险是糖尿病患者的2-4倍。随着研究表明糖尿病发病更早，肥胖人数大幅增加，这一数字只会增加。肥胖导致低度全身炎症，成为心血管疾病的主要因素。一些机构和组织已经记录了有氧运动对成人和儿童在管理糖尿病方面的好处。然而，大多数研究都集中在骨骼肌和胰岛素抵抗上。这项拟议的研究旨在评估有氧运动通过减少脂肪相关炎症来减轻糖尿病心血管效应的影响。Zucker糖尿病肥胖大鼠是一种2型糖尿病模型，将被用来研究我们的假设。评估运动组和久坐组脂肪组织的大小、数量、代谢和细胞因子的变化将有助于更好地了解炎症过程。对前列腺癌2的六跨膜蛋白的检测将为其在脂肪相关炎症中的可能靶点作用提供证据。最后，通过血液动力学监测和血清分析，展示有氧运动对减轻糖尿病心功能障碍的积极作用。长期目标是通过教育规划、生活方式建议和可能的药物干预，为国家卫生研究所在预防2型糖尿病方面的使命提供强有力的支持。相关性：2型糖尿病患者患心脏病的风险显著增加。这项拟议的研究将评估有氧运动在减少脂肪组织炎症方面的好处，脂肪组织的可能调节因素，以及在2型糖尿病动物模型中促进心血管健康的好处。

DESCRIPTION (provided by applicant): As obesity explodes in the United States, the incidence of type 2 diabetes escalates within many populations, particularly in African and Hispanic American groups. Type 2 diabetes presents with devastating complications of the cardiovascular, eye, gastrointestinal, sensory, and integumentary systems. Two out of three diabetic deaths are due to heart disease and stroke. The risk for heart disease is 2-4 times higher for persons with diabetes. The numbers will only grow as research shows earlier onset of diabetes and large increases in the number of obese persons. Obesity causes low-grade systemic inflammation which becomes the primary factor for cardiovascular disease. Several institutions and organizations have documented the benefits of aerobic exercise for adults and children in the management of diabetes. However, the majority of research has focused on skeletal muscle and insulin resistance. The purpose of the proposed study is to evaluate the impact of aerobic exercise on lessening diabetic cardiovascular effects through decreased adipose-related inflammation. The Zucker Diabetic Fatty rat, a model of type 2 diabetes, will be used to investigate our hypothesis. Evaluation of changes in the size, number, metabolism, and cytokines of adipose tissue in exercise and sedentary groups will allow for a greater understanding of the inflammatory process. The examination of six-transmembrane protein of prostate 2, STAMP 2, will provide evidence towards its role as a possible target in adipose-related inflammation. Finally, the demonstration of the positive effects of aerobic exercise on decreasing diabetic cardiac dysfunction will be shown through hemodynamic monitoring and serum analysis. The long-term objective is to provide strong support for the mission of the National Institute of Health in the prevention of Type 2 diabetes through educational programming, lifestyle recommendations, and possible pharmacological interventions. Relevance: Persons with type 2 diabetes present with a substantial increased risk for heart disease. The proposed research will evaluate the benefits of aerobic exercise on reducing inflammation in adipose tissue, possible regulators of adipose tissue, and the promotion of cardiovascular health in a type 2 diabetes animal model.