USC-UCLA Drug-Induced Liver Injjry (DILI) Clinical Center

描述(由申请人提供)： USC-UCLA药物性肝损伤(DILI)临床中心(CC)提案回应 RFA-DK-07-012《药物性肝损伤网络(DILIN)的延续和扩展》希望与其他已建立的CCS联合起来，促进DILI的科学认识和临床评价。我们的计划结合了洛杉矶县仅有的两所医学院，使我们能够在这个庞大的、种族多元化的人口中独特地捕捉帝力病例。洛杉矶县的1030万居民(2007年)是一个无与伦比的资源，由美国最多元化的人口组成。我们建议通过开发针对特定医疗保健提供者群体的教学工具，在南加州大学、加州大学洛杉矶分校和洛杉矶县公共卫生部的医疗保健系统中增加对潜在DILI病例的识别。除了我们独特的患者群体外，这项建议还建立在南加州大学和加州大学洛杉矶分校医学中心的专业知识和人才的基础上。USC-UCLA DILI CC的具体目标是：1)审查现有的DILIN文件，为加入DILIN做准备；2)在南加州大学和加州大学洛杉矶分校建立USC-UCLA DILI CC基础设施；3)建立免费转诊热线，并将IRB批准的文件分发给潜在的医疗保健提供者和药剂师网络，他们将成为潜在DILI病例的转诊来源。4)开发教育工具，以提高对DILI的认识，并加强从附属和非附属医疗保健提供者转诊的DILI病例5)筛选符合条件的受试者并将其纳入DILIN以收集临床数据和标本6)与其他研究人员合作，参与DILIN的组织和运作，并协助设计未来的辅助研究。

DESCRIPTION (provided by applicant): The USC-UCLA Drug Induced Liver Injury (DILI) Clinical Center (CC) proposal in response to RFA-DK-07-012 "Continuation and Expansion of the Drug Induced Liver Injury Network (DILIN)" hopes to joint the other established CCs to advance the scientific knowledge and the clinical evaluation of DILI. Our proposal combines the only two medical schools in Los Angeles County allowing us to uniquely capture DILI cases in this large, ethnically diverse population. The 10.3 M residents of Los Angeles County (2007) are an unmatched resource composed of the most ethnically diverse populations in the United States. We have proposed to increase the identification of potential DILI cases within the health care systems of USC, UCLA and the County of Los Angeles Department of Public Health by developing didactic tools targetted to specific groups of health care providers. In addition to our unique patient population, this proposal is built upon the expertise and talents from the USC and UCLA Medical Centers. The Specific Aims of the USC-UCLA DILI CC are to: 1) Review existing DILIN documents in preparation for joining the DILIN 2) Establish the USC-UCLA DILI CC infrastructure at USC and UCLA, 3) Establish the toll-free referral line and distribute IRB-approved documents to networks of potential health care providers and pharmacists who will be a referral sources for potential DILI cases. 4) Develop educational tools to increase DILI awareness and to enhance DILI case referrals from both affiliated and non-affiliated health care providers 5) Screen and enroll eligible subjects into the DILIN for collection of clinical data and specimens 6) Collaborate with other investigators, participate in the organization and operation of the DILIN, and assist with the design of future ancillary studies.