Cell Biology and Signaling

癌细胞生物学和信号转导 癌症细胞生物学和信号传导计划由来自六个国家的十九名研究人员组成。 部门该项目的使命是阐明细胞信号在调节细胞生长中的作用， 分化和凋亡。该计划侧重于三个主要研究领域：1）了解 参与细胞生长和分化调节的分子机制，重点是 酪氨酸激酶和G蛋白偶联受体信号通路的作用; 2）阐明分子 调节细胞凋亡的机制;和3）解决细胞外基质在调节细胞凋亡中的作用。 细胞生长和迁移。 该计划的一个重要科学目标是整合有关机制的基础研究， 调节细胞生长，分化和细胞凋亡的转化研究工作在KCC。这 这将有助于更好地理解癌症的生物学，也有助于基础研究的转化。 转化为治疗癌症的新策略。所有项目成员均由NIH资助。他们 目前有260万美元的NCI支持和980万美元的同行评审支持。程序 成员共发表了320篇与癌症相关的手稿（8%是计划内的，13%是计划间的） 在最后一个补助期间。

CANCER CELL BIOLOGY AND SIGNALING PROGRAM The Cancer Cell Biology and Signaling Program is comprised of nineteen investigators from six departments. The program mission is to elucidate the role of cell signaling in regulating cell growth, differentiation, and apoptosis. The program focuses on three major areas of research: 1) understanding the molecular mechanisms involved in the regulation of cell growth and differentiation with an emphasis on the role of tyrosine kinase and G protein-coupled receptor signaling pathways; 2) elucidating the molecular mechanisms regulating cell apoptosis; and 3) addressing the role of the extracellular matrix in regulating cell growth and migration. An important scientific goal of this program is to integrate fundamental studies on the mechanisms that regulate cell growth, differentiation, and apoptosis with the translational research efforts at the KCC. This should result in a better understanding of the biology of cancer and also in the translation of basic research into novel therapeutic strategies for the treatment of cancer. All program members are NIH funded. They currently have $2.6 million of NCI support and $9.8 million of total, peer-reviewed support. Program members published a total of 320 cancer-relevant manuscripts (8% intra-programmatic and 13% interprogrammatic) during the last grant period.