Radiation Research and Therapeutics

放射研究和治疗

• 批准号: 8302934
• 负责人: RICHARD G PESTELL
• 金额: $ 3.11万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302934
• 关键词: Angiogenesis Inhibitors; Area; Bioinformatics; Biological Products; Biology; Cancer Center; Cell physiology; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Computers; Developmental Therapeutics Program; Diagnostic; Disease; Early Diagnosis; Elements; Endothelial Cells; Funding; Genotoxic Stress; Goals; Hematologic Neoplasms; Hypoxia; Image; In Vitro; Injury; Investigation; Ionizing radiation; Laboratories; Malignant Neoplasms; Mediator of activation protein; Modification; Molecular Models; Molecular Target; Monitor; New Agents; Normal tissue morphology; Patient Care; Patients; Peer Review; Phase; Pre-Clinical Model; Publications; Radiation; Radiation Oncology; Recurrence; Research; Role; Screening procedure; Staging; Stem cell transplant; Stem cells; Technology; Testing; Therapeutic; Therapeutic Agents; Therapeutic Human Experimentation; Translating; Translational Research; Translations; Work; angiogenesis; base; bench to bedside; clinical application; clinical practice; computer generated; design; in vivo; innovation; interest; member; molecular modeling; multidisciplinary; novel; novel diagnostics; novel therapeutic intervention; novel therapeutics; pre-clinical; programs; research clinical testing; response; structural biology

The new Radiation Research and Translational Biology, (RRTB) program integrates elements from three prior Kimmel Cancer Center programs: Structural Biology and Bioinformatics Program, Developmental Therapeutics Program, and Hematological Malignancies and Stem Cell Transplantation Program. This restructuring was undertaken to leverage key strengths of clinical research at the KCC in Radiation Oncology, Hematological Malignancies, and Stem Cell Transplantation to create a program that conducts bench to bedside research with sustained return of clinical data to the bench in the form of reverse translation. The central themes of the new program include angiogenesis, stem cell function and microenvironmental mediators of the radiation response. The RRTB is an interdisciplinary program comprised of basic, translational and clinical investigators from eight departments and multiple areas of active investigation, interest and expertise. Their work is supported by $18 million in peer-reviewed funding ($16.0 M from NCI). The total number of publications of Program members is 940 of which 16% are Intraprogrammmatic and 14% are Interprogrammatic. The program is a multidisciplinary effort with the goal of defining fundamental mechanisms and targets in radiation research and translational biology, which can facilitate innovations in treating cancer in patients. The specific goals of the RRTB Program are: (1) Define and characterize molecular targets for ionizing radiation. (2) Hypoxia and Angiogenesis: Elucidate mechanisms regulating HIF, integrate angiogenesis inhibitors with ionizing radiation and preclinical and clinical imaging of angiogenesis. (3) Study normal tissue injury/genotoxic stress. (4) Understand radiation target elucidation and modification and (5) Discover and translate diagnostic and therapeutic innovations developed in the laboratories of KCC members to clinical practice. This new program has generated new collaborations within the program and fresh research directions with other research programs in the cancer center.

新的辐射研究和转化生物学（RRTB）计划整合了三个元素 Kimmel癌症中心的项目：结构生物学和生物信息学项目，发展 治疗计划，血液肿瘤和干细胞移植计划。这 进行了重组，以利用KCC在放射方面的临床研究的关键优势 肿瘤学，血液学恶性肿瘤和干细胞移植，以创建一个程序， 实验室到床旁研究，以反向的形式将临床数据持续返回到实验室 翻译.新项目的中心主题包括血管生成、干细胞功能和 辐射反应的微环境介质。RRTB是一个跨学科的计划 由来自八个部门和多个领域的基础，翻译和临床研究人员组成， 积极的调查，兴趣和专业知识。他们的工作得到了1800万美元的同行评审资金的支持 （NCI提供1600万美元）。计划成员的出版物总数为940种，其中16%是 14%是项目内的，14%是项目间的。该计划是一个多学科的努力，目标是 定义辐射研究和转化生物学中的基本机制和靶点， 促进癌症患者治疗的创新。RRTB计划的具体目标是：（1）定义 并表征电离辐射的分子目标。(2)缺氧与血管生成 调节HIF的机制，整合血管生成抑制剂与电离辐射和临床前和 血管生成的临床成像。(3)研究正常组织损伤/遗传毒性应激。(4)了解辐射 靶向阐明和修饰以及（5）发现和转化诊断和治疗创新 在KCC成员的实验室开发的临床实践。这一新方案产生了新的 项目内的合作以及与癌症领域其他研究项目的新研究方向 中心