Radiation Research and Therapeutics

新的辐射研究和翻译生物学(RRTB)计划将三个元素整合在一起 之前的坎摩尔癌症中心项目：结构生物学和生物信息学项目，发展性 治疗计划，以及血液系统恶性肿瘤和干细胞移植计划。这 进行了重组，以利用KCC在放射方面的临床研究的关键优势。 肿瘤学、血液病和干细胞移植创建一个进行 从工作台到床边的研究，将临床数据以反向形式持续返回给工作台 翻译。新计划的中心主题包括血管生成、干细胞功能和 辐射反应的微环境介体。RRTB是一个跨学科的项目 由来自八个部门和多个领域的基础、翻译和临床调查人员组成 积极的调查、兴趣和专业知识。他们的工作得到了1800万美元同行评审资金的支持 (来自NCI的1600万美元)。计划成员的出版物总数为940篇，其中16%是 程序内的和程序间的占14%。该计划是一个多学科的努力，目标是 定义辐射研究和翻译生物学中的基本机制和目标，这可以 促进治疗癌症患者的创新。RRTB方案的具体目标是：(1)确定 并对电离辐射的分子目标进行表征。(2)低氧与血管生成：阐明 调节HIF的机制，整合血管生成抑制剂与电离辐射和临床前和 血管生成的临床影像。(3)研究正常组织损伤/遗传毒性应激。(4)了解辐射 目标阐明和修改以及(5)发现和转化诊断和治疗创新 在KCC成员的实验室中开发并应用于临床。这一新计划产生了新的 该计划内的合作以及与其他癌症研究计划的新研究方向 中间。

The new Radiation Research and Translational Biology, (RRTB) program integrates elements from three prior Kimmel Cancer Center programs: Structural Biology and Bioinformatics Program, Developmental Therapeutics Program, and Hematological Malignancies and Stem Cell Transplantation Program. This restructuring was undertaken to leverage key strengths of clinical research at the KCC in Radiation Oncology, Hematological Malignancies, and Stem Cell Transplantation to create a program that conducts bench to bedside research with sustained return of clinical data to the bench in the form of reverse translation. The central themes of the new program include angiogenesis, stem cell function and microenvironmental mediators of the radiation response. The RRTB is an interdisciplinary program comprised of basic, translational and clinical investigators from eight departments and multiple areas of active investigation, interest and expertise. Their work is supported by $18 million in peer-reviewed funding ($16.0 M from NCI). The total number of publications of Program members is 940 of which 16% are Intraprogrammmatic and 14% are Interprogrammatic. The program is a multidisciplinary effort with the goal of defining fundamental mechanisms and targets in radiation research and translational biology, which can facilitate innovations in treating cancer in patients. The specific goals of the RRTB Program are: (1) Define and characterize molecular targets for ionizing radiation. (2) Hypoxia and Angiogenesis: Elucidate mechanisms regulating HIF, integrate angiogenesis inhibitors with ionizing radiation and preclinical and clinical imaging of angiogenesis. (3) Study normal tissue injury/genotoxic stress. (4) Understand radiation target elucidation and modification and (5) Discover and translate diagnostic and therapeutic innovations developed in the laboratories of KCC members to clinical practice. This new program has generated new collaborations within the program and fresh research directions with other research programs in the cancer center.