QUANTITATIVE CORE

治疗研究中心(TRC)的量化核心为该中心的三项中心和关键活动提供全面和持续的支持：数据管理、统计和经济分析。该核心的具体目标是：(1)提供数据管理，为研究数据的收集、计算机输入和跟踪提供结构、支持、协调和监督，包括所有真相与和解委员会数据的安全性和完整性。(2)为每个成分提供方法学咨询和生物统计分析。(3)评估创新治疗的成本和创新对研究参与者产生的其他卫生保健成本的影响，使用经济模型评估治疗结果，并将这些数据结合在成本-效果分析中。根据我们工作的性质，这一核心与真相与和解委员会的主题密切相关，因为它是所有拟议的真相与和解委员会组成部分和跨组成部分综合研究的关键资源。研究复杂患者的行为需要收集、管理和分析复杂的数据集。围绕这一主题，我们使用了严格的方法，其中大部分来自临床试验，结合了疗效和成本效益分析，做了弥合治疗和服务研究之间差距的工作，并分析了多种风险因素之间的关系，既作为预测因素，也作为时间依赖协变量。该核心提供所有组成部分研究的量化活动，并将其工作与科学和行政核心结合起来。

The Quantitative Core of the Treatment Research Center (TRC) provides full and ongoing supports for three central and critical activities of the Center; data management, statistical, and economic analysis. The specific aims of this Core are; (1) To provide data management by supplying the structure, support, coordination and oversight for collection, computer entry, and tracking of research data including the security and integrity of all TRC data. (2) To provide methodological consultation and biostatistical analyses for each component. (3) To assess the cost of innovative treatments and the impact of the innovations on other health care costs incurred by study participants and to value treatment outcomes using economic models and to combine these data in cost-effectiveness analyses. By the very nature of our work this Core is intimately tied to the theme of the TRC as a key resource for all proposed TRC components and the cross-component integrative studies. Research on the behaviors of complex patients require the collection, management, and analysis of complex datasets. In concert with the theme we use rigorous methodology, much of it derived from clinical trials, combine efficacy and cost-effectiveness analysis, do work that bridges the gap between treatment and services research and analyze relations between multiple risk factors, both as predictors and time dependent covariates. This Core supplies the quantitative activities of all component studies and integrates its work with the Scientific and Administrative Core.