SPORE in Skin Cancer

描述（由申请人提供）：匹兹堡大学和匹兹堡大学癌症研究所建议进行皮肤癌卓越研究（SPORE）的专业计划。匹兹堡大学皮肤癌孢子的总体目标是提高皮肤癌的检测和治疗。SPORE计划将包括六个皮肤癌转化研究项目，四个核心包括行政核心，发展研究计划和职业发展计划。匹兹堡大学皮肤癌孢子将采用跨学科的方法，通过与基础、应用和临床科学的合作研究者开展项目来实现其目标。它也是器官特异性的，因为它的方法和所有项目都将测试有关皮肤癌生物学，易感性，检测或治疗的假设。长期的转化研究项目，将作为改善皮肤癌患者预后的基础。六个主要项目包括：（1）萝卜硫素化学预防黑色素瘤;（2）多抗原工程DC免疫和IFN？转移性黑色素瘤的增强;（3）极化的树突状细胞引导黑素瘤特异性反应;（4）黑素瘤及其肿瘤相关血管表达的EphA 2的治疗性免疫靶向;（5）描绘影响烷化剂治疗黑素瘤功效的DNA修复途径;（6）通过T-lymphocyte耗竭增强用于Sezary综合征的基于树突状细胞的免疫疗法。四个研究核心将密切互动，以协助主要研究项目，发展研究项目和职业发展研究人员开展转化皮肤癌研究。研究的核心是：核心A。管理核心;核心B。组织芯;芯C。免疫监测和细胞制品实验室（IMCPL）;核心D。生物静力学。行政核心将征求内部和外部科学咨询委员会的反馈意见，并为SPORE计划提供科学，监管和财政监督。皮肤孢子研究人员将共同努力，协同实现该计划的目标，并将与其他机构的孢子研究人员互动，以改善皮肤癌患者的预后。

DESCRIPTION (provided by applicant): The University of Pittsburgh and University of Pittsburgh Cancer Institute propose to conduct a Specialized Program of Research Excellence (SPORE) in Skin Cancer. The overall goals of the University Pittsburgh Skin Cancer SPORE are to improve the detection and treatment of skin cancer. The SPORE program will consist of six translational research projects in skin cancer, four cores including an administrative core, a developmental research program and a career development program. The University of Pittsburgh Skin Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co- investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about skin cancer biology, susceptibility, detection, or treatment. The long-term translational research projects that will serve as the basis for improving the outcome of patients diagnosed with skin cancer. The six main projects include: (1) Chemoprevention of Melanoma with Sulforaphane; (2) Multiple Antigen-Engineered DC Immunization and IFN? Boost for Metastatic Melanoma; (3) Polarized Dendritic Cells Guide Melanoma-Specific Responses; (4) Therapeutic Immune Targeting of EphA2 Expressed by Melanoma and Its Tumor-Associated Vasculature; (5) Delineating the DNA Repair pathways impacting alkylating agent efficacy in the treatment of Melanoma; (6) Augmentation of Dendritic Cell-based Immunotherapy for Sezary Syndrome by T-regs depletion. The four research cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational skin cancer research. The research cores are: Core A. Administrative Core; Core B. Tissue Core; Core C. Immunological Monitoring and Cellular Products Laboratory (IMCPL); Core D. Biostatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Skin SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with skin cancer.