Molecular Dissection of the Actin Cytoskeleton in Exocytosis Using Intravital Microscopy

肌动蛋白和原肌球蛋白在细胞中形成网络，这些网络参与了细胞癌变时被劫持的所有关键过程。我们发现原肌球蛋白是网络功能的关键，并已经开发出针对癌症相关原肌球蛋白的药物。我们将使用我们开发的一种新方法来研究这些药物如何杀死癌细胞，以实时显示药物活性，并验证它们对活组织中靶丝的影响。

The proteins actin and tropomyosin form networks in cells that are involved in all of the key processes that are hijacked when a cell becomes cancerous. We discovered that the tropomyosin is the key to the function of a network and have developed drugs that target the cancer-associated tropomyosin. We will examine how the drugs kill cancer cells using a novel method, developed by us, to visualize drug activity in real time, and validate their impact on the target filaments in living tissue.