MONOCLONAL ANTIBODY

单抗核心设备(MACF)不仅提供以下四项高质量的服务 对调查人员来说是合理的费用，但也是及时的。 1.针对感兴趣的特定抗原的新单抗/杂交瘤的产生。 2.单抗的制备(体外)、纯化和修饰(包括与荧光试剂的偶联， 生物作用、酶和单抗的裂解)。 3.组织培养样品的支原体检测。 4.重组/分泌蛋白的体外生产。 单抗是用于生物医学研究的大多数(如果不是全部)领域的基本工具，在 疾病的诊断，以及感染和癌症等疾病的治疗。的目标是 MACF将通过提供与MSKCC调查人员相关的关键服务来支持MSKCC调查人员的研究兴趣 单抗的生产、纯化和使用。 在过去的5年里，对MACF服务的需求一直很高。由2005年7月起 截至2006年7月，来自10个项目中9个项目的61名调查人员向该设施订购了任何 上述服务的组合。

The Monoclonal Antibody Core Facility (MACF) provides the following four high quality services not only at a reasonable cost to investigators but also in a timely manner. 1. The generation of new MAbs / hybridomas to a specific antigen of interest. 2. MAb production (in vitro), purification and modification (including conjugation to fluorphores, biotion and enzymes and the fragmentation of MAbs). 3. Mycoplasma testing of tissue culture samples. 4. In vitro production of recombinant/secreted proteins. Monoclonal antibodies (MAbs) are essential tools used in most if not all fields of biomedical research, in the diagnosis of diseases, and in the treatment of diseases such as infections and cancer. The goal of the MACF is to support the research interests of MSKCC investigators by providing key services related to the production, purification and use of MAbs. Over the last 5 years demand for the MACF services has remained consistently high. From July 2005 through July 2006, 61 investigators from 9 out of 10 programs placed orders with the facility for any combination of the services noted above.