BIOSTATISTICS AND DATA MANAGEMENT CORE

我们建议继续为WFU老年美国人提供生物统计和数据管理核心(RC3) 独立中心(OAIC)。此核心的目标是提供协作支持和其他资源 与以下内容相关： 1.项目的研究设计、样本量确定、数据管理和统计分析(试点和 研究导致与年龄相关的肥胖症增加的多种因素， 骨骼减少，肌肉功能下降，身体功能下降，并进展为残疾。 2.肌肉力量、体能、身体成分、 脂肪分布，以及遗传、生物和残疾测量，加上9个正在进行的外部资助 项目，3个试点，2个研究开发项目(最初一年)。正在进行的收盘 与生物成像、临床研究、分子科学资源以及试点和 探索性研究核心是这一目标的一个重要方面。 3.就与老龄有关的成果的设计、规划、实施和分析对刚果民防中心支助的研究员进行培训 研究项目。 4.现有数据库的数据管理和统计分析(例如，Reaction II、PIE、Train、Health ABC、MESA等)允许重新分析，以解决关于肥胖和 肌肉损失是身体功能下降和进展为身体残疾的决定因素 老年人。 5.数据管理和报告生成，以协助临床研究核心进行监测 招募、遵守和保留，以及分子科学资源核心 促进生物标本库的建立。 6.开发与分析问题直接相关的新生物统计方法和技术 与衰老研究有关。 7.基于网络的工具，有助于领导和行政核心简化沟通和 WFU OAIC内的文件管理。 生物统计和数据管理核心将在方法、统计、质量等方面积极合作 控制和计算问题，包括研究设计、数据收集、计算机联网、数据库 管理、数据分析和成果展示以供发布

We propose continuation of the Biostatistics and Data Management Core (RC3) for the WFU Older Americans Independence Center (OAIC). The aims of this Core are to provide collaborative support and other resources related to: 1. Study design, sample size determination, data management and statistical analysis for projects (pilot and developmental) investigating the multiple factors that contribute to age-related increases in adiposity, sarcopenia, declines in muscle function, physical function decline and progression to disability. 2. Data management and statistical analyses of muscle strength, physical performance, body composition, fat distribution, and genetic, biological, and disability measures that are added to 9 ongoing externallyfunded projects, 3 pilots, and 2 Research Development projects (initial year). The ongoing close collaborations with the Biolmaging, Clinical Research, Molecular Sciences Resource, and Pilot and Exploratory Studies Cores are an important aspect of this aim. 3. Training of RCDC-supported fellows on the design, planning, conduct and analysis of results of agingrelated research projects. 4. Data management and statistical analyses of existing databases (e.g., REACT II, PIE, TRAIN, Health ABC, MESA, etc.) to allow for re-analyses to address scientific questions on the roles of obesity and muscle loss as determinants of the decline in physical function and progression to physical disability in older persons. 5. Data management and report generation to assist the Clinical Research Core with monitoring recruitment, adherence and retention, and the Molecular Sciences Resource Core with monitoring and promoting of a biological specimen repository. 6. Development of novel biostatistical methods and techniques directly related to analytical issues associated with aging research. 7. Web-based tools useful for the Leadership and Administrative Core to streamline communication and document management within WFU's OAIC. The Biostatistics and Data Management Core will actively collaborate on methodological, statistical, quality control and computational issues, including study design, data collection, computer networking, database management, data analysis, and presentation of results for publication