Imaging Core

成像对于研究肌肉骨骼修复和再生对于新的 干预措施和评价对策。核心中心成像核心的广泛目标是 肌肉骨骼修复和再生是提供评估中心，以了解联系 修复和再生的骨骼和软组织的形式和功能之间的关系。具体目标是 在研究人员之间提供合作环境，使用结构（微计算机断层扫描，数字 射线照相术）和分子水平（红外显微镜）成像，以帮助研究人员在选择 相关成像技术，培训新用户，协助开发新方法， 便于使用其他成像模式。核心维持必要的设备、用品和 人员进行红外和微型计算机断层扫描成像，以支持生物医学研究 基地使用其他技术（拉曼光谱、体内生物发光成像、MRI和正电子 发射断层扫描）是通过与其他设施合作提供的。的特定成像 之所以选择核心技术，是因为它们允许确定几何形状和材料 肌肉骨骼结构的特性。任何肌肉骨骼结构的功能表现， 无论是原生的、修复的还是再生的，都取决于几何体、结构和材质属性。 这些性质可以通过显微计算机断层扫描和红外光谱以高空间分辨率进行评估。 显微成像因此，这些成像技术允许分析肌肉骨骼结构 从低到高的分辨率在多个层次：整个骨骼和关节，骨段和软 组织标本，以及组织水平的组成和微观结构。这些成像特性也与 在分析显微镜和机械与材料评估中进行表征 丹

Imaging is critical to studies of musculoskeletal repair and regeneration for both development of new interventions and evaluation of response. The broad objective of the Imaging Core of the Core Center for Musculoskeletal Repair and Regeneration is to provide assessments central to understanding the links between form and function in repaired and regenerated bones and soft tissues. The specific aims are to provide a cooperative environment among researchers using structural (micro-computed tomography, digital radiography) and molecular-level (infrared microscopy) imaging, to assist researchers in the selection of relevant imaging technologies, to train new users, to assist in the development of new approaches, and to facilitate access to other imaging modalities. The Core maintains the necessary equipment, supplies, and personnel to conduct infrared and micro-computed tomography imaging to support the biomedical research base. Access to other techniques (Raman spectroscopy, in vivo bioluminescence imaging, MRI and positron emission tomography) is provided through collaborations with other facilities. The particular imaging techniques of the Core have been chosen because they allow determination of geometry and material properties of musculoskeletal structures. The functional performance of any musculoskeletal structure, whether native, repaired, or regenerated, depends on the geometry, architecture, and material properties. Such properties can be assessed with high spatial resolution by micro-computed tomographic and infrared microscopic imaging. Accordingly, these imaging techniques allow analyses of musculoskeletal structures from low to high resolution at multiple hierarchical levels: whole bones and joints, bone segments and soft tissue specimens, and tissue-level composition and microstructure. These imaging properties also interface with characterizations made in the Analytical Microscopy and the Mechanical and Material Assessment Cores.