Molecular epidemiology of infection in aboriginal communities

众所周知，牙龈组织的破坏性疾病受到诸如糖尿病等全身性疾病、社会经济条件和缺乏对牙龈边缘微生物积累的有效控制等调节因素的深刻影响。这项调查将检验一种假设，即在孤立的、处境不利的土著社区普遍存在的不利修饰因素存在的情况下，由定量分子探针分析确定的有限数量的致病细菌菌株持续存在或重新感染个体，以维持较高的疾病负担。

Destructive diseases of the gum tissue are known to be profoundly affected by modifying factors including systemic diseases such as diabetes, socio-economic conditions and the lack of effective control of microbial accumulation at the gum margin. This investigation will examine the hypothesis that a limited number of pathogenic bacterial strains, defined by quantitative molecular probe analysis, persist in or re-infect individuals to maintain a high disease burden in the presence of adverse modifying factors that prevail in isolated, disadvantaged Aboriginal communities.