EFFECT OF DOXYCYCLINE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多西环素是一种用于治疗细菌感染的治疗药物，已被证明可以减少炎症。本研究的目的是评估多西环素的安全性和有效性，并确定多西他林是否能减轻囊性纤维化患者的炎症反应。选定的CF患者将接受为期28天的多西环素研究药物治疗。在28天的时间里，受试者将通过抽血、肺功能测试、体检和跟踪电话进行密切监测。此外，患者将在服用多西环素后进行为期2周的随访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Doxycycline, a therapeutic drug used to treat bacterial infections and has been shown to decrease inflammation. The purpose of this study is to assess the safety and effectiveness of doxycycline and to determine if doxyxyxline can decrease inflammation in cystic fibrosis patients. Selected CF patients will receive doxycycline study drug treatmetn for a period of 28 days. Subjects will be closely monitored through blood draws, pulmonary function tests, physical exams, and follow up phone calls throughout the 28-day period. In addtiona, patients will be followed for 2 weeks following the doxycycline administration.