DEVELOPMENT AND TESTING OF A 1 YEAR MAINTENANCE INTERVENTION TO REDUCE OBESIT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体目标是设计并测试一项为期8个月的维持计划的效果，该计划旨在延长16周的强化营养和运动干预，以降低超重少数族裔青少年肥胖和2型糖尿病的风险。这项高度创新的为期16周的干预研究名为Sano LA(洛杉矶的力量和营养结果)，目前由美国国立卫生研究院(PI：Dr Michael Goran)资助。我们建议对这项研究进行补充，将干预延长到1年。现有的16周干预和拟议的维护计划将遵循修改的饮食碳水化合物方法(即减少糖和苏打水，增加纤维和全谷物摄入量)以及强化训练方案，我们之前在试点研究中展示了这一方案，以减少少数族裔青年的肥胖并改善胰岛素和血糖动力学。受试者将在最初16周干预开始一年后到GCRC进行测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this study is to design and test the effects of an 8-month maintenance program to extend an intensiove 16-week nutrition and exercise interventio to reduce risk of obesity and type 2 diabetes in 'high-risk' overweight minority adolescents. The highly innovative 16-week intervention study, called SANO LA (Strength and Nutrition Outcomes in Los Angeles) is currently funded by the NIH (PI: Dr Michael Goran). We are proposing a supplement to this study to extend the intervention to 1 year. The Existing 16-week intervention and proposed maintenance program will follow the modified dietary carbohydrate approach (i.e. reduce sugar & soda, increased fiber & whole grain intake) as well as a strengh training protocol, which we have previously shown in pilot studies to reduce adioposity and improve insulin and glucose dynamics in minority youth.Subjects will come to the GCRC at 1 year from the start of the original 16-week intervention for testing.