NONINVASIVE DETERMINATION OF CARDIAC OUTPUT AND CIRCULATING BLOOD VOLUME USIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的主要目标是评估一种在血液透析过程中使用指示剂染料稀释法测量心输出量和循环血容量的方法。了解透析期间的心输出量和血量有助于改善液体管理，预防低血压事件的发生。这项研究的一个基本技术目标是表明，通过非侵入性光学测量注射染料后循环到血液透析器的动脉血中吲哚青绿染料浓度，可以可靠地估计循环血量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our main objective is to assess a method for the measurement of cardiac output and circualting blood volume during hemodialysis using the indicator dye dilution method. Knowledge of cardiac output and blood volume during the dialysis should help improve fluid management and prevent the occurrence of hypotensive episodes. An essential technical goal of the study is to show that circulating blood volume can be reliably estimated by non-invasive optical measurement of indocyanine green dye concentration in arterial blood circulating toward the hemodialyser following dye injection.