EFFECTS OF PIOLITAZONE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这项研究中，我们打算评估激活PPARy的噻唑烷二酮吡格列酮对囊性纤维化患者痰中基质金属蛋白酶-9水平的影响。将开发PK/PD模型来确定第二阶段研究的最佳剂量

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we intend to assess the effect of the PPARy-activating thiazolidinedione pioglitazone on sputum MMP-9 levels in patients with Cystic Fibrosis. A PK/PD model will be developed to determine the optimal dose for phase II studies