EQUIPMENT FOR THE BIO5 ANIMAL FACILITY

描述(由申请者提供)：亚利桑那大学(UA)的研究项目专注于2010年健康人的许多目标，包括通过疾病预防、了解基本的生理和病理过程、发现新的治疗方法以及开发救生技术和仪器来增加亚利桑那州人和美国人的寿命和改善生活质量。动物用途在许多研究领域发挥着至关重要的作用，而动物用途的增加与生物医学研究项目的扩大和大楼的建成不谋而合，这些大楼是新教师的栖息地。其中两座新建筑，基廷生物医学科学和生物技术研究所和医学研究大楼(MRB)，将容纳利用动物的生物医学研究人员。这两栋建筑将共享一个隔间，该隔间将在BIO5第一阶段(2008年秋季开放)中完成。BIO5动物设施将主要致力于基因工程小鼠的生成和维护(40,000只小鼠容量)，并将运营以最大限度地促进小鼠繁殖，同时优化传染病的排除。这项请求的重点是协助为小鼠购买通风住房系统，这些系统将安置在BIO5动物设施。这些设备将用于PHS资助的研究和基因工程小鼠建模核心设施(GEMM Core)，该设施将为许多不同的动物使用者培育小鼠。IVC的使用有很多好处。这些措施包括改善动物和人员的环境，提高饲养动物和研究的生产率，降低研究成本，以及最大限度地增加动物栖息地的能力。购买IVC将促进MICE和人员的福祉，并降低研究成本。

DESCRIPTION (provided by applicant): The University of Arizona's (UA) research programs focus on many of the Healthy People 2010 goals including increasing the life span and improving the quality of life of Arizonans and Americans through disease prevention, understanding of basic physiological and pathological processes, discovery of new treatments, and development of life-saving techniques and instrumentation. Animal use plays a vital role in many areas of research, and increased use of animals has coincided with the expansion of biomedical research programs and completion of buildings, which are housing new faculty recruits. Two of the new buildings, The Keating BIO5 Institute for Biomedical Science and Biotechnology and the Medical Research Building (MRB), are to house biomedical researchers who will utilize animals. The two buildings will share a vivarium, which is being completed in the first phase of BIO5 construction (opening Fall 2008). The BIO5 animal facility will be primarily dedicated to the generation and maintenance of genetically engineered mice (40,000 mouse capacity) and will be operated to maximize mouse reproduction, while also optimizing the exclusion of infectious disease. The focus of this request is to assist in the purchase of ventilated housing systems (IVC) for mice, which will be housed in the BIO5 Animal Facility. The equipment will be utilized for PHS-funded research and for the Genetically Engineered Mouse Modeling Core Facility (GEMM Core), which will generate mice for many different animal users. The use of IVC has many benefits. These include improved environment for animals and personnel, increased productivity of breeding animals and research, reduced costs of research, and the ability to maximize animal housing space. The purchase of the IVC will promote the well-bing of both mice and personnel and provide reduced costs for research.