ANALYSIS OF MULTIPLE RISK FACTORS IN THE ETIOLOGY OF MYOPIA IN CHILDREN

描述（由申请人提供）：近视的高患病率及其作为一个公共卫生问题的突出地位强调了增加对儿童屈光发育的遗传和环境因素的理解的重要性，这是拟议分析的目的。主要目标是通过使用新的方法来分析收集了长达32年的纵向数据，并通过执行这些分析来跟踪最近近视文献中有希望的发现，从而创建一个综合的近视发展风险因素。我们的Access数据库包含来自2090名受试者的超过10,000次折射，110,000次调节测量和近2000次像差测量。据我们所知，这个折射数据库是唯一一个纵向测量开始于婴儿期。这些分析支持了国家眼科研究所斜视、弱视和视觉处理项目未来5年的目标，即“确定人类近视的病因，确定与近视和其他屈光不正相关的风险因素，并确定与控制眼睛生长相关的生化途径。”除了提供近视发展的风险概况外，所提出的分析结果也可能有助于开发新的方法来减缓近视的发展，并确定有效的近视控制干预措施。具体目的如下：具体目的1：研究婴儿屈光不正的发展，探讨儿童及其兄弟姐妹和父母屈光不正的关系。具体目标2：利用新的分析方法和以前没有分析过的数据来研究与近视发展相关的环境因素。具体目标3：整合目标1和目标2中确定的因素以及之前确定的因素，更完整地描述近视发展的风险因素。

DESCRIPTION (provided by applicant): The high prevalence of myopia and its prominence as a public health problem emphasize the importance of gaining increased understanding of the genetic and environmental factors underlying refractive development in children, which the proposed analyses are designed to accomplish. The main goal is to create an integrated account of risk factors for the development of myopia by using new approaches for the analysis of longitudinal data that have been collected for up to 32 years and by performing these analyses to follow up on promising findings from the recent myopia literature. Our Access database has over 10,000 refractions, 110,000 accommodation measurements, and close to 2000 aberration measurements from 2090 subjects. To our knowledge this refraction database is the only one with longitudinal measurements starting in infancy. The analyses support a goal of the Strabismus, Amblyopia, and Visual Processing Program of the National Eye Institute for the next 5 years, which is to "determine the etiology of myopia in humans, identify the risk factors associated with myopia and other refractive errors, and identify the biochemical pathways associated with the control of eye growth." In addition to providing a risk profile for myopia development, results from the proposed analyses also may help to develop new methods to slow the progression of myopia and to identify good candidates for interventions for myopia control. The specific aims are as follows: Specific Aim 1: To study the development of refraction from infancy and to investigate the association of refractive errors in children, their siblings, and their parents. Specific Aim 2: To investigate environmental factors related to myopia development using new analytic approaches and data that have not been analyzed previously. Specific Aim 3: To integrate the factors identified in Aims 1 and 2 and those identified previously into a more complete account of risk factors for myopia development.