Development of a Cognitive Paradigm Ontology: BrainMap and BIRN Intergration

描述（由申请人提供）：本提案的目的是开发、评估和分发认知范式的领域本体，以供功能性神经影像学界应用和使用。这种认知范式本体，CogPO，将通过两个众所周知的和建立的数据库，功能成像生物医学信息学研究网络（FBIRN）人类成像数据库（HID）和BrainMap数据库的集成开发。CogPO的设计集中在可以直接观察到的内容上：根据（1）呈现给受试者的刺激，（2）请求的指令，以及（3）返回的响应对每个范式进行分类。所有的范例基本上都是由这三个正交的组件组成的，围绕它们形式化本体是描述范例的一种清晰而直接的方法。这种结构化的、定义明确的、常见的和受控的词汇表将能够在FBIRN数据库中表示认知范式，该数据库存储结构和功能成像数据集以供以后分析，并且在BrainMap中存储来自功能成像文献的分析结果。该提案旨在包括与国家生物医学本体中心（NCBO）和神经信息学信息框架（NIF）的密切合作。NCBO和NIF目前都没有寻求开发认知范式的本体论;因此，目前的提议是新颖的，并不与任何现有的本体论努力相冲突，而是一种互补的奋进。通过一系列研讨会，CogPO开发人员将咨询领域专家（神经影像研究社区）和本体专家（NCBO）以及BIRN本体任务组（OTF）。CogPO开发人员还计划通过神经影像信息学工具和资源交换所（NITRC）允许整个神经影像社区的用户输入和反馈。该提案包括社区接受开发的本体的正式计划，以及在资助期结束时分发的Protigi-OWL格式的具体可交付成果列表，不仅可供FBIRN和BrainMap用户使用，还可供整个神经成像社区使用。我们的最终目标是将CogPO设计成能够将其扩展到认知科学的更广泛背景。公共卫生相关性：CogPO是认知范式的领域本体，它将以机器可读和机器可解释的方式促进认知实验范式的描述，以允许在不同的数据库和数据源之间进行通信和自动数据共享。该本体将不仅可用于其他fMRI数据库，而且可用于其他神经成像模式的档案（例如，EEG或MEG数据），如神经电磁本体论（NEMO），以及文献神经信息学成果，如神经科学学会的PubMed Plus。我们的最终目标是将CogPO设计成能够将其扩展到认知科学的更广泛背景。

DESCRIPTION (provided by applicant): The objective of this proposal is to develop, evaluate, and distribute a domain ontology of cognitive paradigms for application and use in the functional neuroimaging community. This cognitive paradigm ontology, CogPO, will be developed through the integration of two well known and established databases, the Functional Imaging Biomedical Informatics Research Network (FBIRN) Human Imaging Database (HID) and the BrainMap database. The design of CogPO concentrates on what can be observed directly: categorization of each paradigm in terms of (1) the stimulus presented to the subjects, (2) the requested instructions, and (3) the returned response. All paradigms are essentially comprised of these three orthogonal components, and formalizing an ontology around them is a clear and direct approach to describing paradigms. This structured, well-defined, common and controlled vocabulary will be capable of representing the cognitive paradigms in the FBIRN Data Repository, which stores structural and functional imaging datasets for later analysis, and in BrainMap, which stores analyzed results from the functional imaging literature. This proposal has been designed to include strong collaboration with the National Center for Biomedical Ontology (NCBO) and the Neuroinformatics Information Framework (NIF). Neither the NCBO nor the NIF currently seeks to develop an ontology of cognitive paradigms; thus, the current proposal is novel and does not conflict with any existing ontology efforts, but is a complementary endeavor. Through a series of workshops, CogPO developers will consult both the domain experts (the neuroimaging research community) and the ontological experts (NCBO) and the BIRN Ontology Task Force (OTF). CogPO developers also plan to allow user input and feedback from the entire neuroimaging community through the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). This proposal includes a formal plan for community acceptance of the developed ontology, complete with a list of concrete deliverables in Protigi-OWL format to be distributed by the end of the funding period, which can be utilized not only by FBIRN and BrainMap users, but also by the entire neuroimaging community. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences. PUBLIC HEALTH RELEVANCE: CogPO, a domain ontology of cognitive paradigms, would facilitate descriptions of cognitive experimental paradigms in ways that are machine-readable and machine-interpretable, to allow communication and automated data sharing across diverse databases and data sources. This ontology will be made available for adoption not only by other fMRI databases, but also for archives of other neuroimaging modalities (e.g., EEG or MEG data), such as the Neural ElectroMagnetic Ontologies (NEMO), and literature neuroinformatics efforts such as the Society for Neuroscience's PubMed Plus. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences.