Controlling the adhesome to regulate cell fate on biomaterials

基于间充质干细胞的组织工程实践在世界范围内受到阻碍，因为缺乏对基质介导的线索的认识和理解，而基质介导的线索必须在粘附和扩散过程中提供，以驱动细胞到达确定的组织终点。该项目将通过结合高通量阵列技术、一套可定制的自组装生物材料和实时生物传感器来解决这些知识缺陷，以快速、高分辨率地阐明机械转导线索如何决定间充质干细胞的命运选择，以及如何通过智能生物材料设计来操纵它们，以实现组织工程所需的结果。

Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering.