FLOW EFFECTS OF ENDOTHELIAL/TROPHOBLAST INTERACTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目标： 1.表征切应力对滋养层细胞定向迁移的影响 2.确定趋化因子和内皮细胞黏附分子在切应力介导的滋养层细胞迁移中的作用。 3.确定切应力和滋养层-内皮细胞相互作用对滋养层细胞迁移表型诱导的影响。 4.研究CCR5、RANTES、蛋白多糖和整合素在猕猴子宫侵袭血管中的表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: 1. Characterize the effect of shear stress on the directional migration of trophoblast cells 2. Determine the role of chemokines and endothelial adhesion molecules in shear stress-mediated trophoblast migration. 3. Determine the effect of shear stress and trophoblast-endothelial cell interaction on the induction of a migratory trophoblast phenotype. 4. Characterize the expression of CCR5, RANTES, proteoglycans, and integrins in invaded macaque uterine vessels.