COGNITIVE FUNCTION IN THE AGED MONKEY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：本项目的总体目标是明确正常、非病理性衰老对恒河猴记忆成分过程的影响，并评估这些变化与卵巢激素损伤标志物的关系。一组年轻和年长的受试者接受了一系列经过充分研究的标准化神经心理学任务以及新开发的程序的测试，这些程序旨在为认知老化提供一个敏感的窗口。在整个项目中，所有雌性猴子的尿液激素谱都是定期确定的，以便将这些参数与年龄相关记忆力下降状况的个体差异联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The overall aims of the project are to define the effects of normal, non-pathological aging on the component processes of memory, and to evaluate these changes in relation to markers of ovarian hormone impairment in rhesus monkeys. Groups of young and aged subjects are tested across a battery of well-studied, standardized neuropsychological tasks as well as newly developed procedures designed to provide a sensitive window on cognitive aging. Urinary hormone profiles are determined for all female monkeys periodically throughout the project in order to relate these parameters to individual differences in the status of age-related memory decline.