K23 NEURODEVELOPMENTAL BIOLOGY IN PRESCHOOL CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是更好地了解内分泌系统对应激的生物反应。我们希望这项研究将有助于更好地了解压力激素和大脑发育之间的关系，以及这些激素与儿童行为和家庭压力之间的关系。 参与本研究需要2次研究人员访视;一次访视在受试者家中完成，一次临床访视在GCRC完成。 第一次访视将在签署知情同意书后进行，将包括大约2 - 3小时的结构化访谈问题。 GCRC访视将包括心理测试、测量唾液皮质醇的4份唾液样本以及检查皮质醇、细胞计数、甲状腺功能测试、铅水平、代谢综合征标志物、生长障碍的约30 ml血液样本。此外，还将收集和储存尿液和血液，以备将来可能进行的DNA检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to better understand the biologic response to stress by the endocrine system. We hope that this study will lead to a better understanding of the relationship between stress hormones and the developing brain, and how these are related to child behavior and family stress. Participating in this study will require 2 visits with research personnel; one visit being completed at the participant's home, and one clinical visit to the GCRC. The first visit will occur after informed consent is signed and will include approximately two to three hours of structured interviewing questions. The GCRC visit will include psychological testing, 4 samples of saliva to measure salivary cortisol, and approximately 30 ml sample of blood to examine cortisol, cell count, thyroid function tests, lead levels, markers of metabolic syndrome, growth failure. In addition, urine and blood will be collected and stored for possible DNA testing in the future.