NEUROENDOCRINE FACATORS IN ADOLESCENT DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青春期重度抑郁症（MDD）的患病率在青春期与青春期前相比增加了一倍，并且MDD患病率在性别特异性青春期增加，青春期女孩比男孩发展MDD，这表明正常青春期事件的细微变化可能预测发展MDD的风险。青春期发生的重要变化包括下丘脑-垂体-性腺轴（H-P-G轴）的成熟，其中食欲调节肽ghrelin、瘦素和肽YY（PYY）可能起作用。PYY水平尚未在MDD中进行检查，其与MDD中食欲和骨转换的关系尚不清楚。在这项研究中，我们的目的是比较分泌动力学的生长激素释放肽和瘦素的青春期男孩和女孩与MDD与健康的青春期男孩和女孩的皮质醇和LH分泌，以确定是否MDD发作与特定的变化分泌模式。我们还将确定不同组别中PYY水平与食欲和骨代谢的关系。 将检查选择性5-羟色胺再摄取抑制剂（SSRI）对PYY水平和生长激素释放肽、瘦素、皮质醇和LH分泌动力学的影响，以确定抑郁症状的改善是否与神经内分泌参数恢复正常相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The doubling of the prevalence of major depressive disorders (MDD) during the pubertal vs. the pre-teen years and a gender specific pubertal increase in MDD prevalence with more adolescent girls than boys developing MDD, suggests that subtle alterations in normal pubertal events may predict risk of developing MDD. Important changes occurring at puberty include the maturation of the hypothalamo-pituitary-gonadal axis (H-P-G axis), in which appetite regulating peptides ghrelin, leptin and peptide YY (PYY) may play a role. PYY levels have not been examined in MDD, and their relationship to appetite and bone turnover in MDD is unknown. In this study we aim to compare secretory dynamics of ghrelin and leptin in adolescent boys and girls with MDD vs. healthy adolescent boys and girls in relation to cortisol and LH secretion to determine whether MDD onset is associated with specific changes in secretory patterns. We will also determine PYY levels in different groups in relation to appetite and bone metabolism. Effects of selective serotonin reuptake inhibitors (SSRIs) on PYY levels and on secretory dynamics of ghrelin, leptin, cortisol, and LH will be examined to determine whether improvement in depressive symptoms is associated with restoration of neuroendocrine parameters to normal.