CARDIAC MAGNETIC RESONANCE IMAGING OF MITRAL VALVE PROLAPSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本初步研究的目的是评价心脏磁共振成像（CMR）在评估二尖瓣脱垂（MVP）中的实用性，并研究TGF-β在MVP发病机制中的作用。 这是一项前瞻性队列研究。 研究者计划前瞻性入组60例二尖瓣返流严重程度不同的经典MVP患者：30例仅伴后叶脱垂，30例伴前叶或双叶脱垂。 每组中有一半患者为二尖瓣手术前重度返流患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this pilot study is to evaluate the utility of cardiac magnetic resonance imaging (CMR) in assessing mitral valve prolapse (MVP) and to investigate the role of TGF-¿ in the pathogenesis of MVP. This is a prospective cohort study. The investigators plan to prospectively enroll 60 classic MVP patients with varying mitral regurgitation severity: 30 with posterior leaflet prolapse only and 30 with either anterior or bi-leaflet prolapse. Half the patients in each group will be pre-mitral valve surgery patients with severe regurgitation.