CEREBRAL VASOREGULATION IN ELDERLY WITH STROKE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 中风是第三大死亡原因，也是老年人残疾的主要原因。 本研究的长期目标是确定影响卒中后脑血管调节的因素。主要假设是脑血管调节在老年人中风中受损，脑血流依赖于血压。因此，脑灌注压可能是不同的脑卒中血压正常和脑卒中高血压患者在直立位。第二个假设是中风后自主血压控制改变，使老年人在日常生活活动中易发生直立性低血压（OH）和脑灌注不足。第三个假设是血管反应性受损的区域分布可能超出梗死部位，脑血流可能进一步受到白色物质变化的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death and the leading cause of disability in older people. The long-term goal of this study is to determine factors that effect cerebral vasoregulation after stroke. The primary hypothesis is that cerebral vasoregulation is impaired in older adults with stroke and cerebral blood flow is dependent on blood pressure. Therefore, cerebral perfusion pressure may be different in stroke-normotensive and stroke-hypertensive patients in upright position. The second hypothesis is that autonomic blood pressure control is altered after stroke, predisposing older people to orthostatic hypotension (OH) and cerebral hypoperfusion during activities of daily living. The third hypothesis is that regional distribution of impaired vasoreactivity may extend beyond the infarct site and cerebral blood flow may be further compromised by white matter changes.