STUDY OF GLUTAMINE AND GLUTAMATE METABOLISM IN HEALTHY SUBJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本研究旨在量化健康受试者的全身和内脏区域中谷氨酸/谷氨酰胺代谢利用率、转化率和氧化处理率，这些受试者的饮食遵循常规和谷氨酰胺富集肠内喂养配方的氨基酸组成。 了解谷氨酸和谷氨酰胺的代谢率将进一步有助于检查谷氨酰胺补充剂对健康受试者肌肉蛋白质代谢的支持作用。 这些受试者将作为对照，以评价谷氨酰胺补充剂在重症、严重分解代谢患者中的疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposes to quantify the rates of glutamate/glutamine metabolic utilization, conversion, and oxidative disposal in the whole body and splanchnic region of healthy subjects on a diet that follows the amino acid composition of routine and glutamine-enriched enteral feeding formulas. Understanding the metabolic rate of glutamate and glutamine will further serve to examine the effects of glutamine supplementation on support of muscle protein metabolism in healthy subjects. These subjects will serve as controls to evaluate the efficacy of glutamine supplementation in critically ill, severely catabolic patients.