EXERCISE & URIC ACID LEVELS IN MULTIPLE SCLEROSIS PATIENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尿酸是一种内源性抗氧化剂，是一种重要的自由基的主要清除剂，在几项研究中，自由基被认为对MS中的CNS造成了一些损害。由于尚不清楚的原因，MS患者的尿酸水平低于正常对照。尿酸维持一个典型的昼夜节律，但在正常对照组中，在氧化应激增加的时候，包括运动和暴露于热，尿酸会增加。MS患者？我们想知道MS患者如何应对运动的氧化应激，即他们是否能够适当地提高尿酸水平。我们想让多发性硬化症患者锻炼，然后连续检测一天中的尿酸水平，并与正常对照组进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Uric acid is an endogenous antioxidant, and is the primary scavenger of an important free radical which has been implicated in several studies as causing some of the damage to the CNS in MS. For unclear reasons, MS patients have lower levels of uric acid than normal controls. Uric acid maintains a typical circadian rhthym, but in normal controls is increased in times of increased oxidative stress, including exercise and exposure to heat. MS patients?We are wondering how MS patients respond to the oxidative stress of exercise in terms of whether or not they are able to raise their uric acid levels appropriately. We want to exercise MS patients, and then check successive uric acid levels throughout the day, and compare this with normal controls.