Calcium Phosphate Bone Cement Nanocomposites

描述（申请人提供）：磷酸钙骨水泥（CPC）用于骨科手术中作为骨填充物，已被证明具有非常好的生物相容性。然而，尽管其具有良好的生物相容性，但其机械性能不足，严重阻碍了其临床应用。Nanova Inc.正在开发含有超强和超长羟基磷灰石（HA）纤维的新型骨水泥纳米复合材料。人们希望这种新型磷酸钙骨水泥纳米复合材料具有良好的生物相容性以及足够的机械性能，作为骨植入材料用于许多骨科应用，如普通骨移植、假体固定、平台骨折固定、椎体成形术和椎体后凸成形术等。目前使用PMMA骨水泥的假体固定市场约为2亿美元。我们相信，磷酸钙骨水泥，如果强大和坚韧，将接管目前的PMMA的市场。Nanova Inc.根据我们的市场分析，预计坚韧磷酸钙骨水泥的市场可能超过10亿美元。这种坚韧的磷酸钙骨水泥纳米复合材料将使全世界数百万患者受益，并将为美国的医疗保健做出重大贡献。在这项高影响力和创新性研究中获得的知识将有利于其他领域的研究，如硬组织工程和其他非生物医学纳米复合材料。 公共卫生相关性：Nanova Inc.正在开发含有羟基磷灰石（HA）纤维的磷酸钙骨水泥纳米复合材料，其机械性能显著改善。这种纳米复合材料具有以下骨科应用，如一般骨移植、假体固定、平台骨折固定、椎体成形术和椎体后凸成形术，它们将使数百万骨折患者受益。

DESCRIPTION (provided by applicant): Calcium phosphate cements (CPCs) are used in orthopedic surgery as bone filler and have been proved with very good biocompatibility. However, the inadequate mechanical properties have significantly impeded their clinical applications despite of the good biocompatibility. Nanova Inc. is developing novel bone cement nanocomposites containing super-strong and ultra-long hydroxyapatite (HA) fibers. It is hoped that the novel calcium phosphate cement nanocomposites will have excellent biocompatibility as well as sufficient mechanical properties as a bone implant materials for many orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty and kyphoplasty, etc. The current prosthesis fixation using PMMA bone cements has a market of about $200 million. We believe that the calcium phosphate cements, if made strong and tough, will take over the current PMMA's market. Nanova Inc. estimated that the strong and tough calcium phosphate cements may have a market over $1 billion based on our marketing analysis. The strong and tough calcium phosphate cement nanocomposites will benefit the millions of patients world wide and will be a major contribution for the healthcare in the United States. The knowledge gained in this high-impact and innovative research will benefit research in other fields, such as hard tissue engineering and other non-biomedical nanocomposites. PUBLIC HEALTH RELEVANCE: Nanova Inc. is developing calcium phosphate bone cement nanocomposites containing hydroxyapatite (HA) fibers with significantly improved mechanical properties. Such nanocomposites have the following orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty, and kyphoplasty, and they will benefit millions of patients with bone fracture.