MAGNETIC FIELD THERAPY IN DIABETIC PERIPHERAL NEUROPATHY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 糖尿病神经病变（DPN）影响50%的糖尿病患者，导致最长神经变性，导致感觉丧失、疼痛和虚弱。疼痛和截肢的风险是最常见的相关残疾。DPN的疼痛是由于小神经纤维的异常放电以及钠和钙通道的积聚。 脉冲磁场诱导极低频（ELF）电流，导致神经变得难以进一步放电。 我们推测，将磁场引导到脚底可能会减少导致DPN疼痛的异常神经放电。 目的：确定在3个月的时间内，疼痛性DPN受试者每天接受2小时脉冲电磁场治疗（PEMF）是否可以： 1. 降低神经性疼痛评分 2. 提高生活质量 3. 导致神经再生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetic neuropathy (DPN) affects 50% of patients with diabetes, resulting in degeneration of the longest nerves, resulting in sensory loss, pain and weakness. Pain and risk for foot amputation are the most common associated disabilities. Pain in DPN results from abnormal firing of small nerve fibers with accumulation of sodium and calcium channels. Pulsed magnetic fields induce extremely low-frequency (ELF) currents, which cause nerves to become refractory to further firing. We hypothesize that directing a magnetic field into the soles of the feet may reduce abnormal nerve firing responsible for DPN pain. Objectives: To determine if two hours of daily Pulsed Electromagnetic Field Therapy (PEMF) in subjects with painful DPN over a three-month period of time can: 1. Reduce neuropathic pain scores 2. Improve quality of life 3. Result in nerve regeneration.