FSH AND THE ONSET OF PUBERTY--GANIRELIX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定青春期时间的差异是否可以解释为FSH调节肽控制下FSH加工的改变。 我们将通过比较性早熟和青春期延迟儿童FSH控制的调节，确定这些肽与青春期前和青春期儿童FSH产生的关系。 在这项初步研究中，我们将使用GnRH激动剂刺激青春期轴，以确定青春期对激活素A、促性腺激素A和促性腺激素B的反应。 B和卵泡抑素。 为了确定FSH分泌和FSH调节肽张力的基线，我们将用特异性拮抗剂阻断GnRH。 这些研究将有助于更好地了解FSH在控制青春期开始和青春期疾病发病机制中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this research is to determine whether differences in the timing of puberty may be explained by alterations in the elaboration of FSH under the control of the FSH-regulatory peptides. We will determine how these peptides relate to FSH production in prepubertal and pubertal children by comparing the regulation of FSH control in children with precocious puberty and delayed puberty. In this pilot study, we will stimulate the pubertal axis using an agonist of GnRH to determine the pubertal response of activin-A, inhibin-A and B and follistatin. To determine baseline FSH secretion and FSH-regulatory peptide tone, we will block GnRH with a specific antagonist. These studies should lead to a better understanding of the role of FSH in controlling the onset of puberty and the pathogenesis of pubertal disorders.