RELATIONSHIP BETWEEN INSULIN RESISTANCE & EARLY DEV OF ATHEROGENESIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的中心焦点是胰岛素介导的葡萄糖处置和代偿性高胰岛素血症在调节增加冠心病（CHD）风险的代谢变化中的重要性。 这些可能包括更明显的众所周知的CHD风险因素，如血脂异常和高血压以及其他导致称为X综合征的异常簇的因素。 除了关注这些风险因素外，我们还将评估内皮依赖性血管舒张（内皮依赖性血管反应性，EDVR）和内皮-单核细胞相互作用决定因素的变化，这些因素构成动脉粥样硬化形成的最早阶段。 因此，我们将试图建立胰岛素抵抗和与胰岛素作用缺陷相关的代谢异常簇之间的联系。 我们还将尝试建立胰岛素抵抗和内皮依赖性血管舒张以及内皮-单核细胞相互作用的决定因素之间的联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study has been on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of metabolic changes that increase risk of coronary heart disease (CHD). These can include more obvious well-known CHD risk factors, such as dyslipidemia and hypertension and others leading to the cluster of abnormalities known as Syndrome X. Besides focusing on these risk factors, we will also evaluate changes in endothelium-dependent vasodilation (endothelium-dependent vascular reactivity, EDVR) and determinants of endothelial-monocyte interaction that comprise the earliest steps in atherogenesis. Therefore, we will be attempting to establish a link between insulin resistance and the cluster of metabolic abnormalities associated with this defect in insulin action. We will also try and establish the link with insulin resistance and endothelium-dependent vasodilatation and determinants of endothelium-monocyte interaction.