IN VIVO STUDIES OF INSULIN SECRETION AND RESISTANCE IN FAMILIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自研究开始以来，这项研究的重点一直是调节胰岛素刺激的葡萄糖处置和葡萄糖刺激的胰岛素分泌的因素。特别是，重点在于证明脂肪组织在这些过程中发挥着核心作用。基于我们的研究结果以及其他人的相关发现，本研究的目的是检验以下假设：1)胰岛素抵抗个体对给定的血糖浓度增加所反应的胰岛素分泌增加；2)胰岛素抵抗个体中，游离脂肪酸(FFA)浓度升高对葡萄糖刺激的胰岛素分泌的抑制作用被夸大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of this research, since its inception, has been on factors regulating insulin-stimulated glucose disposal and glucose-stimulated insulin secretion. In particular, emphasis has been placed on demonstrating that adipose tissue plays a central role in these processes. Based upon the results of our studies, as well as relevant findings of others, the goal of this study is to test the following hypotheses: 1) insulin secretion in response to a given increment in plasma glucose concentration is enhanced in insulin-resistant individuals; and 2) the inhibition of glucose-stimulated insulin secretion by elevated free fatty acid (FFA) concentrations is exaggerated in insulin-resistant individuals.