RENALASE EXPRESSION IN CKD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肾上腺素能血管反应性增强导致高血压和肾功能恶化，导致慢性肾脏疾病(CKD)。肾酶是儿茶酚胺代谢和维持血压(BP)所必需的一种关键酶。该项目将检验肾酶水平随着慢性肾脏病进展而降低的假设，以及这些降低的水平与儿茶酚胺水平的升高有关。 1.测定慢性肾脏病各期患者的血清肾酶水平。 2.探讨血清肾酶水平与CKD分期及肾小球滤过率的关系。 3.测定血清肾素酶、儿茶酚胺与血压的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Enhanced adrenergic vascular reactivity significantly contributes to hypertension and deterioration of renal function leading to chronic kidney disease (CKD). Renalase is a critical enzyme that is required for the metabolism of catecholamines and maintenance of blood pressure (BP). This project will test the hypothesis that renalase levels decrease with progressive CKD and that these decreased levels are associated with increased catecholamine levels. 1. To determine serum renalase levels in individuals with all stages of CKD. 2. To correlate serum renalase levels and the stage of CKD as well as estimated GFR. 3. To determine the relationship between serum renalase, catecholamine, and blood pressure.