CHRONIC KIDNEY DISEASE IN CHILDREN PROSPECTIVE COHORT STUDY (CKID)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标： 1. 确定儿童CKD进展的新型和传统肾脏疾病风险因素（例如GFR下降） 2.描述肾功能下降对神经发育、认知能力和行为的影响。 3.确定进行性CKD中传统和新型心血管疾病风险因素的患病率和演变。 4.检查GFR下降对生长和生长失败治疗的影响，并评估生长失败对CKD儿童发病率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. Identify novel and traditional renal disease risk factors for the progression of CKD (e.g. decline of GFR) in children 2. Characterize the impact of a decline in kidney function on neurodevelopment, cognitive abilities, and behavior. 3. Identify the prevalence and evolution of traditional and novel cardiovascular disease risk factors in progressive CKD. 4. Examine the effects of declining GFR on growth and the treatment of growth failure, and to assess the consequences of growth failure on morbidity in children with CKD.